Ações do Zinco na Saúde Humana – Artigo 9
Zinc and Oxidative Stress: Current Mechanisms
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules,
contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functio...
Ações do Zinco na Saúde Humana – Artigo 19
Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease
Background: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellular second
messenger that controls many processes associated with insulin signaling and other downstream pathways that are amendable to glycemic control. Main body: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transporter ...
Ações do Zinco na Saúde Humana – Artigo 12
Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes. In pancreatic ...
Ações do Zinco na Saúde Humana – Artigo 17
Zinc Signals and Immunity
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency as well as zinc excess result in severe disturbances in immune cell numbers and activities, which can result in increased susceptibility to infections and development of especially inflammatory diseases. This review focuses on the role of zinc in regulating intracellular signaling pathways in innate as well as adaptive immune cells. Main underlying molecular mechanisms and targets affected by
altered zinc homeostasis, including kinases, caspases, phosphatases, and phosphodi...
Ações do Zinco na Saúde Humana – Artigo 18
Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized
Controlled Trial
Background: Data have shown that healthy children and adolescents have an inadequate intake of zinc, an essential nutrient for growth. It is unclear whether zinc supplementation can enhance bone health during this rapid period of growth
and development.
Objective: The primary aim of this study was to determine the effect of zinc supplementation on biochemical markers of
bone turnover and growth in girls entering the early stages of puberty. The secondary aim ...
Ações do Zinco na Saúde Humana – Artigo 20
Zinc, aging, and immunosenescence: an overview
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence.
Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.
Ações do Zinco na Saúde Humana – Artigo 14
Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis
Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer among African Americans. We examined the association between self-reported zinc intake and prostate cancer in a hospital-based case-control study of ...
