Agrotóxicos e efeitos à saúde – Artigo 16
Pesticide use and risk of end-stage renal disease among
licensed pesticide applicators in the Agricultural Health Study
Objectives—Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 41 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study (AHS), a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina.
Methods—Via linkage to the United States Renal Data System, we identified 320 ...
Agrotóxicos e efeitos à saúde – Artigo 6
Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated
Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a
Native American Population
Background: Exposure to persistent organic pollutants (POPs) is known to increase risk of diabetes.
Objective: To determine which POPs are most associated with prevalence of diabetes in 601 Akwesasne Native Americans.
Methods: Multiple logistic regression analysis was used to assess associations between quartiles of concentrations of 101 polychlorinated biphenyl (PCBs) congeners, congener groups and three ...
Agrotóxicos e efeitos à saúde – Artigo 14
Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study
BACKGROUND: Some epidemiologic and laboratory studies suggest that insecticides are related to increased breast cancer risk, but the evidence is
inconsistent. Women engaged in agricultural work or who reside in agricultural areas may experience appreciable exposures to a wide range of
insecticides.
OBJECTIVE: We examined associations between insecticide use and breast cancer incidence among wives of pesticide applicators (farmers) in the prospective
Agricultural Health Study.
METHODS: Farmers ...
Agrotóxicos e efeitos à saúde – Artigo 2
A Systems Biology Approach Reveals Converging Molecular Mechanisms
that Link Different POPs to Common Metabolic Diseases
A number of epidemiological studies have identified statistical associations between
persistent organic pollutants (POPs) and metabolic diseases, but testable hypotheses regarding underlying molecular mechanisms to explain these linkages have not been published.
Objectives: We assessed the underlying mechanisms of POPs that have been associated with metabolic diseases; three well-known POPs [2,3,7,8-tetrachlorodibenzodioxin (TCDD), 2,2´,4,4´,5,5´-hexachlorobiphenyl ...
Agrotóxicos e efeitos à saúde – Artigo 18
Synergistic Effects of Heavy Metals and Pesticides in Living Systems
There is a widespread repeated exposure of the population to the pesticides and
heavy metals of occupational and environmental origin. Such population is forced to
undergo continuous stress imposed by combined exposure of the heavy metals and
different classes of the pesticides used in agricultural as well as health practices. The
existing reports from several workers have indicated that heavy metals and pesticides
in combination may lead more severe impact on the human health when compared to
their individual ...
Agrotóxicos e efeitos à saúde – Artigo 10
Exposure to organophosphorus and organochlorine pesticides, perfluoroalkyl substances, and polychlorinated biphenyls in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC Study
Background: Studies report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Environmental chemicals may increase the risk of diabetes through impacts on glucose metabolism, mitochondrial dysfunction, and endocrine-disrupting mechanisms including effects on pancreatic β-cell function and adiponectin release.
Objectives: To ...
Agrotóxicos e efeitos à saúde – Artigo 15
Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats
Increasing evidence indicates that chlorpyrifos (CPF), an organophosphorus insecticide, is involved in metabolic disorders. We assess the hypothesis whether supplementation with prebiotics from gestation to adulthood, through a modulation of microbiota composition and fermentative activity, alleviates CPF induced metabolic disorders of 60 days old offspring. 5 groups of Wistar rats, from gestation until weaning, received two doses of CPF pestic...
Agrotóxicos e efeitos à saúde – Artigo 8
Early-life chemical exposures and risk of metabolic syndrome
The global prevalence of obesity has been increasing at a staggering pace, with few
indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology ...
