Chá verde e efeitos à saúde – Artigo 02
Comparative effects of selected plant polyphenols, gallic acid
and epigallocatechin gallate, on matrix metalloproteinases
activity in multidrug resistant MCF7/DOX breast cancer cells
The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and
obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX). The ...
Chá verde e efeitos à saúde – Artigo 01
Anti-Cancer Effects of Green Tea by Either Anti- or Pro-
Oxidative Mechanisms
Tea derived from the leaves and buds of Camellia sinensis (Theaceae) is consumed worldwide. Green tea
contains various components with specific health-promoting effects, and is believed to exert protective effects
against diseases including cancer, diabetes and hepatitis, as well as obesity. Of the various tea components, the
polyphenol catechins have been the subject of extensive investigation and among the catechins, (-)-epigallocatechin
gallate has the strongest bioactivity in most cases. Our research group ...
Nutrição e Fertilidade – Artigo 20
Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis
Zinc is an essential trace mineral for the normal functioning of the male reproductive system. Current studies have investigated the relationship between seminal plasma zinc and male infertility but have shown inconsistent results. Hence, we systematically searched PubMed, EMBASE, Science Direct/ Elsevier, CNKI and the Cochrane Library for studies that examined the relationship between seminal
plasma zinc and male infertility, as well as the effects of zinc supplementation ...
Nutrição e Fertilidade – Artigo 19
Zinc Levels in Seminal Fluid in Infertile Males and its Relation with Serum Free Testosterone
Introduction: The role of zinc is critical to reproduction potential. Seminal zinc is thought to be derived almost exclusively from prostatic secretions. Sperm motility is significantly influenced by zinc. Zinc deficiency has been linked with male sterility and subfertility.
Aim: To assess the influence of seminal plasma zinc on seminogram characteristics and whether endogenous testosterone affects the seminal levels of zinc. Materials and Methods: The semen samples were obtained from 150 male ...
Nutrição e Fertilidade – Artigo 18
The zinc spark is an inorganic signature of human egg activation
Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation ...
Nutrição e Fertilidade – Artigo 17
The role of vitamin D in reproductive dysfunction in women – a systematic review
Vitamin D is essential for the proper functioning of the human body. There is also evidence of its strong association with fertility problems in women. This review aims to evaluate the relationship between vitamin D and diseases affecting women’s fertility (polycystic ovarian syndrome (PCOS), uterine leiomyomas and endometriosis), and in vitro fertilization (IVF) outcome. A systematic review of the literature was conducted in Scopus and PubMed for relevant English language publications since 1989. ...
