Nutrição e Esteatose hepática não alcoólica – Artigo 12
Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
Abstract: Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disorders ranging from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFL increases the risk of liver fibrosis. If the liver is fatty due to causes of insulin resistance such as obesity and physical inactivity, it overproduces glucose and triglycerides leading to hyperinsulinemia and a low high-density lipoprotein (HDL) cholesterol concentration. The latter features ...
Nutrição e Esteatose hepática não alcoólica – Artigo 11
Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper
Abstract: Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes, due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in addition to excessive dietary fat and carbohydrate intake. Chronic hepatic lipid overload induces mitochondrial oxidative stress and cellular damage leading the development of NAFLD into a more severe liver disease condition, non-alcoholic steato-hepatitis (NASH). In turn, this can progress to cirrhosis and h...
Nutrição e Esteatose hepática não alcoólica – Artigo 10
Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease
Abstract: Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical ...
Nutrição e Esteatose hepática não alcoólica – Artigo 9
Medical nutrition therapy in non-alcoholic fatty liver disease – a review of literature
Abstract
Background and aim: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide, with a prevalence of 20%-40% in Western populations. The purpose of this article is to review data related to lifestyle changes in patients with NAFLD.
Method: We searched a public domain database (PubMed) with the following categories: disease (NAFLD, fatty liver, and nonalcoholic steatohepatitis [NASH]) and intervention (lifestyle intervention, diet, nutrition) with each ...
Nutrição e Esteatose hepática não alcoólica – Artigo 8
L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway
Abstract
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease characterized by lobular
inflammation, hepatocellular ballooning, and fibrosis with an inherent risk for progression to cirrhosis and hepatocellular carcinoma (HCC). Mitochondrial dysfunction appears to play a role in the progression from simple steatosis to NASH. Lcarnitine (L-b-hydroxy-g-N-trimethylaminobutyric acid), an essential nutrient that converts fat ...
Nutrição e Esteatose hepática não alcoólica – Artigo 7
Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic
Risk Individuals
Abstract: Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and ...
Nutrição e Esteatose hepática não alcoólica – Artigo 6
Gut-Liver Axis, Nutrition, and Non Alcoholic Fatty Liver Disease
Abstract
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases involving hepatic fat accumulation, inflammation with the potential progression to fibrosis and cirrhosis over time. NAFLD is often associated with obesity, insulin resistance, and diabetes. The interactions between the liver and the gut, the so-called ”gut-liver axis”, play a critical role in NAFLD onset and progression. Compelling evidence links the gut microbiome, intestinal barrier integrity, and NAFLD. The dietary factors may ...
Nutrição e Esteatose hepática não alcoólica – Artigo 5
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
Abstract: Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these metabolic diseases remains debated. Mechanistically, hepatic fructose metabolism yields precursors that can be used for gluconeogenesis and de novo lipogenesis (DNL). Fructose-derived precursors also act as nutritional regulators of the transcription factors, including ChREBP and SREBP1c, that regulate the expression ...
