Nutrição e Envelhecimento – Artigo 20
Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study
Abstract
Summary—Vitamin D deficiency was common in older adults from a country with adequate sun exposure. The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly.
Purpose—The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults.
Methods—This was a secondary ...
Nutrição e Envelhecimento – Artigo 19
Vitamin C, Aging and Alzheimer’s Disease
Abstract: Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate ...
Nutrição e Envelhecimento – Artigo 18
Vitamin B12 deficiency and impaired expression of amnionless during aging
Abstract
Background: Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitamin B12 deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether aging and frailty associate with altered vitamin B12 homeostasis in humans and investigated the underlying ...
Nutrição e Envelhecimento – Artigo 17
TOR-mediated regulation of metabolism in aging
Summary
Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms. The nutrient-sensing pathway is regulated at the lysosomal membrane by a number of proteins for which deficiency triggers widespread aging phenotypes in tested animal models. In response to environmental ...
Nutrição e Envelhecimento – Artigo 16
The influence of vitamins E and C and exercise on brain aging
Abstract
Age-related declines in motor and cognitive function have been associated with increases in oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would be capable of preventing or reducing functional declines occurring during aging. Popular interventions such as antioxidant intake and moderate exercise are often recommended to attain healthy aging and have the capacity to alter redox burden. This review is intended to summarize the outcomes of antioxidant supplementation (more ...
Nutrição e Envelhecimento – Artigo 15
Serum Tocopherol Levels and Vitamin E Intake are Associated with Lung Function in the Normative Aging Study
Abstract
Background and Aims—The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting. This study aimed to evaluate the effect of vitamin E intake and serum levels of tocopherol isoforms on lung function in a cross-sectional sample of 580 men from the Normative Aging Study, a longitudinal aging study.
Methods—Regression models were used to look at associations of serum tocopherol isoform levels and vitamin E ...
Nutrição e Envelhecimento – Artigo 14
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
Abstract
All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model organisms ranging from yeast to non-human primates. In this review, we discuss the effects of a CR diet on metabolism and healthspan, and highlight emerging evidence that suggests ...
Nutrição e Envelhecimento – Artigo 13
Proteostasis, oxidative stress and aging
ABSTRACT
The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive
species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of
mammalian cells, systems are necessary which regulate and preserve a functional cellular protein pool, in a
process termed “proteostasis”. Not only the mammalian protein pool is subject of a constant turnover, organelles
are also degraded and rebuild. The most important systems for these removal processes are the ...
