Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 2
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways
Abstract: Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the noninflammatory patients (n = 7) into another subset with a B cell signature. The inflammatory subset was remarkable for granulocyte and agranulocyte diapedesis, hepatic fibrosis, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 1
A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy
Abstract
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS oxidative stress clouds corresponding conclusions. Therefore, we construct a comprehensive, temporal view of oxidative stress and corresponding antioxidant ...
Nutrição e Fibromialgia – Artigo 20
Identifcation of candidate genes associated with fbromyalgia susceptibility in southern Spanish women: the al‑Ándalus project
Abstract
Background: Candidate-gene studies on fbromyalgia susceptibility often include a small number of single nucleo‑ tide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefore, we compared genotype frequencies of candidate SNPs in a well-characterised sample of Spanish women with fbromyal‑ gia and healthy non-fbromyalgia women.
Methods: A total of 314 women with a diagnosis of fbromyalgia ...
Nutrição e Fibromialgia – Artigo 19
AAPT Diagnostic Criteria for Fibromyalgia
Abstract: Fibromyalgia (FM) is a common chronic pain disorder that presents diagnostic challenges for clinicians. Several classification, diagnostic and screening criteria have been developed over the years, but there continues to be a need to develop criteria that reflect the current understanding of FM and are practical for use by clinicians and researchers. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration ...
Nutrição e Fibromialgia – Artigo 18
Vitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary Results
Abstract
Background: Vitamin D deficiency and insufficiency have been reported in fibromyalgia. However, to the best of our knowledge, only one study has evaluated the role of 25- hydroxyvitamin D [25(OH)D] supplementation on fibromyalgia symptoms.
Objectives: To analyze the effects of 3 months of 25(OH)D supplementation on symptoms of fibromyalgia.
Methods: This study included 11 female patient. Demographic and clinical data, tender points, visual analog scale results, and pre- and post-se...
Nutrição e Fibromialgia – Artigo 17
Vitamin D and fibromyalgia: a meta-analysis
Abstract
Vitamin D is a cofactor responsible for autoimmune disorders. There is no agreement in the studies investigating
the association between vitamin D and fibromyalgia. This study aims to combine the conflicting results of the
primary studies which compared these patients with control groups regarding the serum concentration of
vitamin D. This meta-analysis has been designed based on PRISMA guidelines. Relevant keywords were
searched in PubMed, Science direct, Scopus, Cochrane, and Google scholar and primary studies were selected.
...
Nutrição e Fibromialgia – Artigo 16
Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A
systematic review and meta-analysis
Abstract
Background: Many chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) patients (35–68%)
use nutritional supplements, while it is unclear whether deficiencies in vitamins and minerals contribute to symptoms in these patients. Objectives were (1) to determine vitamin and mineral status in CFS and FMS patients as compared to healthy controls; (2) to investigate the association between vitamin and mineral status and clinical parameters, including ...
Nutrição e Fibromialgia – Artigo 15
The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review
Abstract
Background: Fibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways. Little is known about its role in fibromyalgia. We performed a systematic literature review to determine if vitamin D contributes to the pathology and disability of patients with fibromyalgia, and to assess the role of vitamin D supplementation in disease manage...
