Nutrição e Esteatose Hepática não alcoólica – Artigo 19
Thymoquinone reverses nonalcoholic fatty liver disease (NAFLD) associated with experimental hypothyroidism
Abstract
Objectives: To assess the efficacy of thymoquinone (TQ), the most active constituent in Nigella sativa, which is a medicinal plant from the Ranunculaceae family, in restoring the normal liver structure after 6-propyl-2-thiouracil (PTU)-induced hypothyroidism and explore the mechanism behind this. Materials and Methods: Hypothyroidism was induced in rats by injection of PTU [6 mg/kg body weight (b.w.)] for six weeks. Twenty-four adult male Wistar rats were divided into ...
Nutrição e Esteatose Hepática não alcoólica – Artigo 18
The Role of Probiotics in Nonalcoholic Fatty Liver Disease: A New Insight into Therapeutic Strategies
Abstract: Nonalcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of pathological hepatic conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which may predispose to liver cirrhosis and hepatocellular carcinoma (HCC). Due to the epidemic obesity, NAFLD is representing a global health issue and the leading cause of liver damage worldwide. The pathogenesis of NAFLD is closely related to insulin resistance (IR), adiposity and physical inactivi...
Nutrição e Esteatose Hepática não alcoólica – Artigo 17
The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with
Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized
Controlled Trial
Abstract: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation. This study aims to evaluate the effects of two personalized energy-restricted diets on the liver status in overweight or obese subjects with NAFLD after a 6 months follow...
Nutrição e Esteatose Hepática não alcoólica – Artigo 16
Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men
Abstract
Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLDrelated serum parameters and the activity of antioxidant enzymes, before and after 3 months of ...
Nutrição e Esteatose Hepática não alcoólica – Artigo 15
Role of Probiotics in Non-alcoholic Fatty Liver Disease: Does Gut Microbiota Matter?
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the hepatic consequence of metabolic syndrome, which often also includes obesity, diabetes, and dyslipidemia. The connection between gut microbiota (GM) and NAFLD has attracted significant attention in recent years. Data has shown that GM affects hepatic lipid metabolism and influences the balance between pro/anti-inflammatory effectors in the liver. Although studies reveal the association between GM dysbiosis and NAFLD, decoding the mechanisms of ...
Nutrição e Esteatose Hepática não alcoólica – Artigo 14
Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach
ABSTRACT
Background: Toxicant-associated steatohepatitis has been described in adults but less is known regarding the role
of toxicants in liver disease of children. Perfluoroalkyl substances (PFAS) cause hepatic steatosis in rodents, but
few previous studies have examined PFAS effects on severity of liver injury in children.
Objectives: We aimed to examine the relationship of PFAS to histologic severity of nonalcoholic fatty liver disease (NAFLD) in children.
Methods: ...
Nutrição e Esteatose Hepática não alcoólica – Artigo 13
Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments
Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma. Metabolic disorders, such as lipid accumulation, insulin resistance, and inflammation, have been implicated in the pathog...
Nutrição e Esteatose Hepática não alcoólica – Artigo 12
Nonalcoholic fatty liver disease and alcoholic liver disease: metabolic diseases with systemic manifestations
Abstract: The progression of liver disease is portrayed by several common, overarching signs and symptoms. Classically, these include findings such as spider angiomata, jaundice, palmar erythema, and as cirrhosis decompensates, ascites, variceal hemorrhage (VH), hepatic encephalopathy (HE), and hepatocellular carcinoma (HCC). Aside from these universal hallmarks among cirrhotics, patients with nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) harbor ...
