Nutrição e Sistema Imune – Artigo 5
A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection
Abstract: Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response. Adequate amounts are essential to ensure the proper function of physical ...
Nutrição e Sistema Imune – Artigo 4
Immune Function and Micronutrient Requirements Change over the Life Course
Abstract: As humans age, the risk and severity of infections vary in line with immune competence according to how the immune system develops, matures, and declines. Several factors influence the immune system and its competence, including nutrition. A bidirectional relationship among nutrition, infection and immunity exists: changes in one component affect the others. For example, distinct immune features present during each life stage may affect the type, prevalence, and severity of infections, while poor ...
Nutrição e Sistema Imune – Artigo 3
Zinc Signals and Immunity
Abstract: Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency as well as zinc excess result in severe disturbances in immune cell numbers and activities, which can result in increased susceptibility to infections and development of especially inflammatory diseases. This review focuses on the role of zinc in regulating intracellular signaling pathways in innate as well as adaptive immune cells. Main underlying molecular mechanisms and targets affected by altered zinc homeostasis, including kinases, caspases, phosphatases, ...
Nutrição e Sistema Imune – Artigo 2
Zinc in Human Health: Effect of Zinc on Immune Cells
Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East. The zinc-deficient patients had severe immune dysfunctions, inasmuch as they died of intercurrent infections by the time they were 25 years of age. In our studies in an experimental human model of zinc deficiency, we documented decreased serum testosterone level, oligospermia, severe immune dysfunctions mainly affecting T helper cells, hyperammonemia, ...
Nutrição e Sistema Imune – Artigo 1
Zinc: dietary intake and impact of supplementation on immune function in elderly
Abstract The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an adequate
healthy status leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases. Nutrient “zinc” is a relevant micronutrient involved in maintaining a good integrity of many body homeostatic mechanisms, including immune efficiency, owing to its requirement for the biological activity of many enzymes, proteins and for cellular ...
Nutrição e Diabetes Mellitus Gestacional – Artigo 23
Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33
Lycium barbarum L. (LBL) has beneficial effects on gestational diabetes mellitus (GDM) but the related mechanism remains unclear. Polysaccharides of LBL (LBLP) are the main bioactive components of LBL. miR-33, ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding transcription 1 (SREBF1) affect lipid profiles, which are associated with GDM risk. LBLP ...
Nutrição e Diabetes Mellitus Gestacional – Artigo 22
Higher maternal dietary protein intake is associated with a higher risk for gestational diabetes mellitus in a multi-ethnic Asian cohort
Abstract
Background—Dietary protein may affect glucose metabolism through several mechanisms, but results from studies on dietary protein intake and risk of gestational diabetes mellitus (GDM) have been inconsistent.
Objective—We examined the cross-sectional associations of dietary protein intake from different food sources during pregnancy with the risk for GDM in a multi-ethnic Asian population.
Methods—We included 980 participants with ...
Nutrição e Diabetes Mellitus Gestacional – Artigo 21
Dietary iron intake, iron status, and gestational diabetes
ABSTRACT
Pregnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplementation. Emerging evidence from both animal and population-based studies, however, has raised potential concerns because significant associations have been observed between greater iron stores and disturbances in glucose metabolism, including increased risk of type 2 diabetes among nonpregnant individuals. Yet, the evidence is uncertain regarding the role of ...
