Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 16
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Abstract | Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to behavioural responses, such as avoidance and alarm, that are likely to have provided early humans with an evolutionary advantage in their interactions with pathogens and predators. However, in modern times, such interactions between inflammation and the brain appear to drive the development of depression and may contribute to non-responsiveness to current antidepressant therapies. Recent data have ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 15
Relações Neutrófilo-Linfócito e Plaqueta-Linfócito como Preditores de Insuficiência Cardíaca
Resumo
Fundamento: A relação neutrófilo-linfócito (RNL) e a relação plaqueta-linfócito (RPL) são novos biomarcadores
inflamatórios usados como fatores prognósticos em várias doenças.
Objetivos: Comparar a RPL e a RNL de pacientes com insuficiência cardíaca (IC) àquelas de controles pareados por
idade e sexo, avaliar o valor preditivo desses marcadores na detecção de IC, e demonstrar o efeito da RPL e da RNL na mortalidade de pacientes com IC durante o seguimento.
Mét...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 14
Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals
Abstract: It has become increasingly evident that chronic inflammation underpins the development of many chronic diseases including cancer, cardiovascular disease and type 2 diabetes. Oxidative stress is inherently a biochemical dysregulation of the redox status of the intracellular environment, which under homeostatic conditions is a reducing environment, whereas inflammation is the biological response to oxidative stress in that the cell initiates the production of proteins, enzymes, and ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 13
Innate immune activation in neurodegenerative disease
Abstract | The triggering of innate immune mechanisms is emerging as a crucial component of major neurodegenerative diseases. Microglia and other cell types in the brain can be activated in response to misfolded proteins or aberrantly localized nucleic acids. This diverts microglia from their physiological and beneficial functions, and leads to their sustained release of pro-inflammatory mediators. In this Review, we discuss how the
activation of innate immune signalling pathways — in particular, the NOD-, LRR- and pyrin domain-con...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 12
Average Values and Racial Differences of Neutrophil Lymphocyte Ratio among a Nationally Representative Sample of United States Subjects
Abstract
Introduction: Several studies reported the negative impact of elevated neutrophil/lymphocyte ratio (NLR) on outcomes in many surgical and medical conditions. Previous studies used arbitrary NLR cut-off points according to the average of the populations under study. There is no data on the average NLR in the general population. The aim of this study is to explore the average values of NLR and according to race in adult non-institutional United ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 11
Proteína C reativa de alta sensibilidade como biomarcador de risco na doença coronária
Resumo A inflamação vascular tem um papel crucial na patogénese da aterosclerose e medeia vários dos estados de desenvolvimento da placa de ateroma, desde a formação da estria lipídica à destabilização e rotura da placa que precede as síndromes clínicas da doença cardiovascular. Os biomarcadores inflamatórios constituem uma ferramenta valiosa para acompanhar a evolução deste processo, permitindo mensurar o efeito das diversas atitudes terapêuticas implementadas. Neste contexto, a ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 9
Inflammatory Mechanisms in Obesity
Keywords
adiposity, metaflammation, insulin resistance, inflammatory signaling,organelle stress, nutrient signals
Abstract
The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these pathologies. The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research field that examines the inflammatory mechanisms in obesity. Here, we
summarize the unique features of this metabolic inflammatory state, termed metafl...
