Nutrição e Degeneração Macular – Artigo 9
Fatores modificáveis da degeneração macular relacionada à idade
Resumo
Os autores apresentam os principais fatores modificáveis considerados de risco para o desencadeamento e/ou agravamento da degeneração macular relacionada com a idade. São abordados os mecanismos de ação destes fatores, assim como medidas preventivas e eficácia de eventuais intervenções.
Descritores: Tabagismo; Hipertensão; Hipercolesterolemia; Aterosclerose; Índice de massa corporal; Raios ultravioleta; Luz; Antioxidantes; Carotenóides; Luteína; Ácidos graxos ômega-3; Dieta; Degeneração macular; ...
Nutrição e Degeneração Macular – Artigo 8
Degeneração macular relacionada à idade: novas perspectivas
Resumo
A degeneração macular relacionada à idade (DMRI) é a principal causa de cegueira legal em indivíduos acima de 50 anos de idade. Embora estudos recentes tenham mostrado que o fator genético é significativo, a patogênese da degeneração macular relacionada à idade permanece obscura, e os fatores de risco não estão ainda completamente estabelecidos. Estudos multicêntricos randomizados, publicados nos últimos anos, demonstraram que uma combinação de vitaminas e minerais é eficaz na redução do risco de ...
Nutrição e Degeneração Macular – Artigo 7
Association between dietary fats and age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women’s Health Initiative
Abstract
Objective—Evaluating relationships of amount and type of dietary fat to intermediate AMD. Design—Women, ages 50–79, from the Women’s Health Initiative-Observational Study, with high and low lutein intakes, were recruited into the Carotenoids in Age-Related Eye Disease Study (CAREDS). Fat intake in 1994–1998 was estimated using food frequency questionnaires. AMD was assessed in ...
Nutrição e Degeneração Macular – Artigo 6
Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS)
PURPOSE. We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS).
METHODS. Of 2005 CAREDS participants, 1663 were graded for AMD from fundus photography and genotyped for 424 single nucleotide polymorphisms (SNPs) from 24 candidate genes for carotenoid status. Of 337 AMD cases 91% had early or intermediate AMD. The SNPs ...
Nutrição e Degeneração Macular – Artigo 5
A Systematic Review on Zinc for the Prevention and Treatment of Age-Related Macular Degeneration
PURPOSE. The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD.
METHODS. Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods and/or supplements, and AMD in men and women with a mean age of 50 years or older were included. Medline and Cochrane Central were searched from inception to February 2012 and ...
Nutrição e Degeneração Macular – Artigo 4
REVIEW ARTICLE
Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy
Abstract
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated ...
Nutrição e Degeneração Macular – Artigo 3
Obesity, Lutein Metabolism, and Age-Related Macular Degeneration: A Web of Connections
Abstract
Age-related macular degeneration (AMD) is a major cause of visual impairment in the United States. Currently there is no effective cure for this disease. Risk factors include decreased lutein and zeaxanthin status and obesity. Obesity is also an increasing public health concern. The alarming increase in the prevalence of obesity further exacerbates the public health concern of AMD. The mechanism by which obesity increases the risk of AMD may be related to the physiologic changes that occur with ...
Nutrição e Degeneração Macular – Artigo 2
Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized,
Controlled Trial
Abstract: Lutein is selectively incorporated into the macula and brain. Lutein levels in the macula (macular pigment; MP) and the brain are related to better cognition. MP density (MPD) is a biomarker of brain lutein. Avocados are a bioavailable source of lutein. This study tests the effects of the intake of avocado on cognition. This was a six-month, randomized, controlled trial. Healthy subjects consumed one avocado (n = 20, 0.5 mg/day lutein, AV) vs. one potato or one cup of chickpeas ...
