Nutrição e Hiperhomocisteinemia – Artigo 3
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
Abstract
Hyperhomocysteinemia is recognized as a risk factor for several diseases, including cardiovascular and neurological conditions. Homocysteine (HCys) is a key metabolite involved in the biosynthesis andmetabolismofmethionine (Met),which plays a pivotal role in the physiological cell’s life cycle. The biochemistry of Met is finely regulated by several enzymes that control HCys concentration. Indeed, balanced activity among the enzymes is essential for the cell’s well-being, while its ...
Nutrição e Hiperhomocisteinemia – Artigo 2
Influence of Dietary Supplementation for Hyperhomocysteinemia Treatments
Abstract: Hyperhomocysteinemia is recognized as risk factor for cardiovascular and age-associated diseases. Folic acid supplementation eciently lowers plasma homocysteine (Hcy) levels, but high intake may negatively aect health because of unnatural levels of unmetabolized folic acid in the systemic circulation. Oxoproline (Oxo) provides by glutamic acid production an increase of intracellular folic acid trapping. Aim of this study was to compare the ecacy of three supplementation protocols: (1) traditional therapy ...
Nutrição e Hiperhomocisteinemia – Artigo 1
The metabolism and significance of homocysteine in nutrition and health
Abstract
An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur
containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was
subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer’s disease, Parkinson’s disease, stroke, and cardiovascular disease (CVD). Also, Hcy is associated with (but not limited to) cancer, aortic aneurysm, hypothyroidism and end renal stage disease to ...
