Daniel Barreto de Melo
Nutricionista | Prof. Ed. Física | CRN-3 43696
Mestre em Ciências (Alergia e Imunopatologia) (FM/USP)
Título de Especialista em Fitoterapia (ASBRAN)
Esp. Nutrição aplicada ao Exercício (EEFE/USP)
Esp. Fisiologia do Exercício e Treinamento Resistido (FM/USP)
Circulating plasma microRNAs dysregulation and metabolic endotoxemia induced by a high-fat high-saturated diet
Summary
High-fat diet increase two to three times the plasma lipopolysaccharide (LPS) levels and induce subclinical inflammation. Diet can modify gene expression due to epigenetic processes related to MicroRNAs (miRNAs). MicroRNAs (miRNAs) play important role in the post-transcriptional mechanisms involved in regulation of express...
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
Abstract | In terrestrial vertebrates, bone tissue constitutes the ‘osteoimmune’ system, which functions as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where haematopoietic stem cells are maintained. Bone and mineral metabolism is maintained by the balanced action of bone cells such as osteoclasts, osteoblasts and ...
Sleep and inflammation: partners in sickness and in health
Abstract | The discovery of reciprocal connections between the central nervous system, sleep and the immune system has shown that sleep enhances immune defences and that afferent signals from immune cells promote sleep. One mechanism by which sleep is proposed to provide a survival advantage is in terms of supporting a neurally integrated immune system that might anticipate injury ...
Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, ...
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty yearsago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss ...
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids
Abstract: Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic inflammatory response is an acute reaction to infections or to tissue injuries, and it tends to move towards resolution and homeostasis. However, the inflammatory process that was observed in ...
NF‑κB, inflammation, immunity and cancer: coming of age
Abstract | Fourteen years have passed since nuclear factor‑κB (NF‑κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. ...
