Innate immune activation in neurodegenerative disease
Abstract | The triggering of innate immune mechanisms is emerging as a crucial component of major neurodegenerative diseases. Microglia and other cell types in the brain can be activated in response to misfolded proteins or aberrantly localized nucleic acids. This diverts microglia from their physiological and beneficial functions, and leads to their sustained release of pro-inflammatory ...
Average Values and Racial Differences of Neutrophil Lymphocyte Ratio among a Nationally Representative Sample of United States Subjects
Abstract
Introduction: Several studies reported the negative impact of elevated neutrophil/lymphocyte ratio (NLR) on outcomes in many surgical and medical conditions. Previous studies used arbitrary NLR cut-off points according to the average of the populations under study. There is no data on the average ...
Proteína C reativa de alta sensibilidade como biomarcador de risco na doença coronária
Resumo A inflamação vascular tem um papel crucial na patogénese da aterosclerose e medeia vários dos estados de desenvolvimento da placa de ateroma, desde a formação da estria lipídica à destabilização e rotura da placa que precede as síndromes clínicas da doença cardiovascular. Os biomarcadores inflamatórios constituem uma ferramenta ...
Diet, gut microbiota and immune responses
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a dietmicrobiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
Inflammatory Mechanisms in Obesity
Keywords
adiposity, metaflammation, insulin resistance, inflammatory signaling,organelle stress, nutrient signals
Abstract
The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these pathologies. The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research ...
Higher than Normal Plasma Iinterleukin-6 Concentrations in Brazilian Patients with Mood Disorders
ABSTRACT
The aim of this work was to study the plasma concentration of IL-6 by ELISA in the patients with mood disorders
and normal healthy donors. The plasma concentration of IL-6 was higher in the patients than in the control healthy
group. Results suggested that IL-6 could serve as an immunological marker in mood disorder pathogenesis as ...
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression
ABSTRACT
Background: The intake of glucose or a high-fat, high-carbohydrate (HFHC) meal, but not orange juice, induces an increase in inflammation and oxidative stress in circulating mononuclear cells (MNCs) of normal-weight subjects.
Objective: We investigated the effect of orange juice ...
Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
OBJECTIVE — We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononucl...
