Zinc, aging, and immunosenescence: an overview
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence.
Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible ...
Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis
Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer ...
Atrazine induced epigenetic transgenerational
inheritance of disease, lean phenotype and
sperm epimutation pathology biomarkers
Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions of the herbicide atrazine. Atrazine is one of the most commonly ...
Pesticide use and risk of end-stage renal disease among
licensed pesticide applicators in the Agricultural Health Study
Objectives—Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 41 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study (AHS), a prospective cohort ...
Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated
Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a
Native American Population
Background: Exposure to persistent organic pollutants (POPs) is known to increase risk of diabetes.
Objective: To determine which POPs are most associated with prevalence of diabetes in 601 Akwesasne Native Americans.
Methods: Multiple logistic regression ...
Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study
BACKGROUND: Some epidemiologic and laboratory studies suggest that insecticides are related to increased breast cancer risk, but the evidence is
inconsistent. Women engaged in agricultural work or who reside in agricultural areas may experience appreciable exposures to a wide range of
insecticides.
OBJECTIVE: We examined associations between ...
A Systems Biology Approach Reveals Converging Molecular Mechanisms
that Link Different POPs to Common Metabolic Diseases
A number of epidemiological studies have identified statistical associations between
persistent organic pollutants (POPs) and metabolic diseases, but testable hypotheses regarding underlying molecular mechanisms to explain these linkages have not been published.
Objectives: We assessed the underlying mechanisms of POPs ...
Synergistic Effects of Heavy Metals and Pesticides in Living Systems
There is a widespread repeated exposure of the population to the pesticides and
heavy metals of occupational and environmental origin. Such population is forced to
undergo continuous stress imposed by combined exposure of the heavy metals and
different classes of the pesticides used in agricultural as well as health practices. The
existing reports from several workers ...
