Nutrição e Esteatose – Artigo 12
Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy
Abstract: The gut microbiota plays critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes(T2D), and insulin resistance(IR), highlighting the potential of gut microbiota-targeted therapies in these diseases. There are various ways that gut microbiota can be manipulated, including through use of robiotics, prebiotics, synbiotics, antibiotics, and some active components from herbal medicines. In this review, we review the main ...
Nutrição e Esteatose – Artigo 11
Gut-Liver Axis, Nutrition, and Non Alcoholic Fatty Liver Disease
AbstractNonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases involving hepatic fat accumulation, inflammation with the potential progression to fibrosis and cirrhosis over time. NAFLD is often associated with obesity, insulin resistance, and diabetes. The interactions between the liver and the gut, the so-called ”gut-liver axis”, play a critical role in NAFLD onset and progression. Compelling evidence links the gut microbiome, intestinal barrier integrity, and NAFLD. The dietary factors may alter ...
Nutrição e Esteatose – Artigo 10
Nutrition, nonalcoholic fatty liver disease and the microbiome: recent progress in the field
AbstractPurpose of review—Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selectednutrients to NAFLD. Recent findings—To understand the effect of diet, the microbiome must be considered because it is the interface of diet and the liver. Early studies suggest that the characteristic of the ...
Nutrição e Esteatose – Artigo 9
Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease1–3
ABSTRACTNonalcoholic fatty liver disease (NAFLD) can range in spectrum from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which ischaracterized by lipotoxicity, hepatocellular ballooning, and inflammation and can progress to cirrhosis. Weight loss is the cornerstone treatment for NAFLD and NASH. Various randomized controlled trials have shown that weight loss of $5–10% leads to significant improvements in hepatic steatosis. Diets high in sodium and fructose have been implicated in ...
Nutrição e Esteatose – Artigo 8
Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity (1). Indeed, metabolic syndrome and insulin resistance play a role in the pathogenesis of NAFLD, which involves intrahepatic triglyceride accumulation and inflammation (2). NAFLD is a consequence of genetic predisposition interacting with environmental and behavioral factors. Data within the ...
Nutrição e Esteatose – Artigo 7
Dietary approach in the treatment of nonalcoholic fatty liver disease
AbstractNonalcoholic fatty liver disease (NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome (MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentiallynonalcoholic steatohepatitis (NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. ...
Nutrição e Esteatose – Artigo 6
Mediterranean diet and nonalcoholic fatty liver disease
AbstractNonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstoneof ...
Nutrição e Esteatose – Artigo 5
Nutritional Intake and the Risk for Non-Alcoholic Fatty Liver Disease (NAFLD)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising worldwide, and it is estimated that approximately one billion individuals may be afflicted with NAFLD globally [1,2]. This epidemic has created a large demand for therapeutic interventions in order to treat patients at riskfor the development of end-stage liver disease. As NAFLD is a slowly progressive disease along a spectrum that covers (i) hepatic steatosis defined as non-alcoholic fatty liver (NAFL), (ii) inflammatory non-alcoholic ...
