Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 16
Lead, cadmium and mercury in cerebrospinal fluid and risk of amyotrophic lateral sclerosis: a case-control study
Abstract
Exposure to neurotoxic chemicals such as pesticides, selenium, and heavy metals have been
suggested to play a role in the etiology of amyotrophic lateral sclerosis (ALS). We assessed
exposure to lead, cadmium, and mercury in 38 ALS patients (16 men and 22 females) and 38
hospital-admitted controls by using their cerebrospinal fluid (CSF) content as biomarker. We
determined CSF heavy metal levels with inductively coupled plasma sector field mass
spectrometry, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 15
Intakes of caffeine, coffee and tea and risk of Amyotrophic Lateral Sclerosis: Results from five cohort studies
Abstract
Objective—Caffeine is thought to be neuroprotective by antagonizing the adenosine A2A
receptors in the brain and thereby protecting motor neurons from excitotoxicity. We examined the association between consumption of caffeine, coffee and tea and risk of Amyotrophic Lateral
Sclerosis (ALS).
Methods—Longitudinal analyses based on over 1 010 000 men and women in 5 large cohort
studies [the Nurses’ Health Study, the Health Professionals Follow-up Study, the ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 14
Feeding Tubes and Health Care Service Utilization in Amyotrophic Lateral Sclerosis: Benefits and Limits to a Retrospective, Multicenter Study Using Big Data
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurologic disorder with predictable challenges regarding disease progression and end-of-life care. These include need for respiratory and nutritional support. Little is known about how such choices impact end-of-life health service utilization for these patients. Using OptumLabs Data Warehouse, a large
administrative claims database with more than 150 million ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 13
Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions
Abstract: A growing number of preclinical and human studies demonstrate a disease-modifying effect of nutritional state in amyotrophic lateral sclerosis (ALS). The management of optimal nutrition in ALS is complicated, as physiological, physical, and psychological effects of the disease need to be considered and addressed accordingly. In this regard, multidisciplinary care teams play an integral role in providing dietary guidance to ALS patients and their carers. However, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 12
Enteral feeding through endoscopic gastrostomy in amyotrophic lateral sclerosis
patients
Nutrición enteral por gastrostomía endoscópica en pacientes con esclerosis lateral amiotrófica
Resumen
Introducción: la disfagia es común en pacientes con esclerosis lateral amiotrófi ca (ELA) y pude resultar en desnutrición. Se recomienda la gastrostomía endoscópica (PEG) cuando la alimentación oral no es más segura. Este trabajo tiene como objetivo evaluar la efi cacia y seguridad de la alimentación por PEG en la mejora de los parámetros nutricionales y de pronóstico en pacien...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 11
Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis
Abstract: In this review, we summarize the most important recent developments in the
treatment of amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment
options, several drugs such as dexpramipexole, pioglitazone, lithium, and many others have been tested in large multicenter trials, albeit with disappointing results. Therefore, riluzole remains the only directly disease-modifying drug. In addition, we discuss antisense
oligonucleotides (ASOs) as a new and potentially causal treatment ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 10
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention
Summary
In mutant SOD1 transgenic mouse models, a high‑caloric, high‑fat diet or ketogenic diet generally had protective effects on ALS; however, in the mouse models, the pathogenesis is mainly associated with oxidative stress. The effect of energy intake and diets on other ALS mechanisms should be further investigated. On the other hand, studies have provided certain evidences to support hypercaloric nutrition as a potential intervention for ALS patients, but large sample‑size, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 9
Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis
Abstract
Background: Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal cord.
Objective: We analyzed the spinal cords of G93A mice following dietary D3 restriction at 2.5% the adequate intake (AI) for oxidative damage ...
