Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 14
Feeding Tubes and Health Care Service Utilization in Amyotrophic Lateral Sclerosis: Benefits and Limits to a Retrospective, Multicenter Study Using Big Data
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurologic disorder with predictable challenges regarding disease progression and end-of-life care. These include need for respiratory and nutritional support. Little is known about how such choices impact end-of-life health service utilization for these patients. Using OptumLabs Data Warehouse, a large
administrative claims database with more than 150 million ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 13
Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions
Abstract: A growing number of preclinical and human studies demonstrate a disease-modifying effect of nutritional state in amyotrophic lateral sclerosis (ALS). The management of optimal nutrition in ALS is complicated, as physiological, physical, and psychological effects of the disease need to be considered and addressed accordingly. In this regard, multidisciplinary care teams play an integral role in providing dietary guidance to ALS patients and their carers. However, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 12
Enteral feeding through endoscopic gastrostomy in amyotrophic lateral sclerosis
patients
Nutrición enteral por gastrostomía endoscópica en pacientes con esclerosis lateral amiotrófica
Resumen
Introducción: la disfagia es común en pacientes con esclerosis lateral amiotrófi ca (ELA) y pude resultar en desnutrición. Se recomienda la gastrostomía endoscópica (PEG) cuando la alimentación oral no es más segura. Este trabajo tiene como objetivo evaluar la efi cacia y seguridad de la alimentación por PEG en la mejora de los parámetros nutricionales y de pronóstico en pacien...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 11
Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis
Abstract: In this review, we summarize the most important recent developments in the
treatment of amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment
options, several drugs such as dexpramipexole, pioglitazone, lithium, and many others have been tested in large multicenter trials, albeit with disappointing results. Therefore, riluzole remains the only directly disease-modifying drug. In addition, we discuss antisense
oligonucleotides (ASOs) as a new and potentially causal treatment ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 10
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention
Summary
In mutant SOD1 transgenic mouse models, a high‑caloric, high‑fat diet or ketogenic diet generally had protective effects on ALS; however, in the mouse models, the pathogenesis is mainly associated with oxidative stress. The effect of energy intake and diets on other ALS mechanisms should be further investigated. On the other hand, studies have provided certain evidences to support hypercaloric nutrition as a potential intervention for ALS patients, but large sample‑size, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 9
Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis
Abstract
Background: Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal cord.
Objective: We analyzed the spinal cords of G93A mice following dietary D3 restriction at 2.5% the adequate intake (AI) for oxidative damage ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 8
Dietary intake and zinc status in amyotrophic lateral sclerosis patients
Ingesta dietética y estado de zinc en pacientes con esclerosis lateral amiotrófica
Resumen
Introducción: hay pruebas considerables de que los cambios en la homeostasis del zinc están relacionados con la patogénesis de la esclerosis lateral amiotrófica (ELA) y que la malnutrición es un factor pronóstico capaz de reducir la supervivencia de los pacientes con ELA.
Objetivo: evaluar la ingesta dietética y el estado de zinc en pacientes con ELA, tratados en un centro de atención ambulatoria especializado en ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 7
Complementary and Alternative Therapies in ALS
Synopsis
Given the severity of their illness and lack of effective disease modifying agents, it is not
surprising that most patients with ALS consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and energy healing. This chapter reviews these in detail. We also describe 3 models by which physicians may frame discussions about alternative therapies: paternalism, autonomy and shared decision making. ...
