Nutrição e Hemocromatose – Artigo 9
The effect of dietary iron intake on the development of iron overload among homozygotes for haemochromatosis
Abstract
Objective: To quantify the role of dietary Fe in total body Fe (TBI) accumulation among homozygotes for the HFE gene associated with haemochromatosis.
Design: A Monte Carlo model was built to simulate Fe accumulation based on findings from human feeding experiments and national dietary surveys. A hypothetical cohort of 1000 homozygotes with starting age 25 years was used in 39-year simulations. The impact of reducing dietary Fe intake on Fe accumulation was tested.
Res...
Nutrição e Hemocromatose – Artigo 8
Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic review
ABSTRACT
Background: Hereditary hemochromatosis (HH) leads to iron loading because of a disturbance in the negative-feedback mechanism between dietary iron absorption and iron status. The management of HH is achieved by repeated phlebotomies.
Objective: We investigated whether HH patients would benefit from a diet with low iron intake and bioavailability.
Design: We performed a systematic review of studies that linked iron bioavailability and status with dietary factors in ...
Nutrição e Hemocromatose – Artigo 7
HFE hemochromatosis: an overview about therapeutic recommendations
A B S T R A C T
Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency. Large advances in the knowledge on the hemochromatosis pathophysiology have occurred due to a better understanding of the protein of the iron metabolism, the genetic basis of hemochromatosis and of other iron overload diseases or conditions which can lead to this phenotype. In the present review, the main aims are to show updates on hemochromatosis and to report a practical set of therapeutic recommendations for ...
Nutrição e Hemocromatose – Artigo 6
The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis
Abstract
Objectives We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH).
Methods We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-...
Nutrição e Hemocromatose – Artigo 5
A Hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro
Resumo
A anemia por deficiência de ferro caracteriza-se como o mais prevalente problema nutricional em todo o mundo. Nesta revisão reuniu-se informações a respeito do metabolismo da hepcidina, avaliando-se seu valor como parâmetro bioquímico na anemia por deficiência de ferro. Realizou-se um levantamento bibliográfico nas bases de dados PUBMED e LILACS, período 2006-2010, referentes à hepcidina como um biomarcador para a regulação do metabolismo do ferro. Foram localizados 35 estudos ...
Nutrição e Hemocromatose – Artigo 4
Hemocromatose hereditária: revisão de literatura
RESUMO
Introdução: A hemocromatose hereditária (HH) é doença caracterizada pelo aumento de ferro no organismo. Sua classificação é feita de acordo com a alteração genética, podendo ser do tipo 1, ligada ao gene HFE; do tipo 2A, ligada ao gene da hemojuvelina; 2B, ligada ao gene HAMP; tipo 3, ligada a alterações no gene dos receptores da transferrina (TFR2); e tipo 4, ligada a alterações no gene da ferroportina (SLC40A1).
Objetivos e Metodologia: O objetivo geral deste estudo de revisão bibliográfica foi descrever a ...
Nutrição e Hemocromatose – Artigo 3
Managing Genetic Hemochromatosis: An Overview of Dietary Measures, Which May Reduce Intestinal Iron Absorption in Persons With Iron Overload
Abstract
Genetic hemochromatosis causes iron overload by excess absorption of dietary iron, due to a decreased expression of hepcidin. The objective was to elaborate dietary recommendations that can reduce intestinal iron absorption in hemochromatosis patients, based on our present knowledge of the iron contained in nutrients and the mechanisms of iron uptake. This is a narrative review. Literature search in PubMed and Google Scholar of papers ...
Nutrição e Hemocromatose – Artigo 2
Dietary and Sentinel Factors Leading to Hemochromatosis
Abstract: Although hereditary hemochromatosis is associated with the mutation of genes involved in iron transport and metabolism, secondary hemochromatosis is due to external factors, such as intended or unintended iron overload, hemolysis-linked iron exposure or other stress-impaired iron metabolism. The present review addresses diet-linked etiologies of hemochromatosis and their pathogenesis in the network of genes and nutrients. Although the mechanistic association to diet-linked etiologies can be complicated, the stress sentinels ...
