Nutrição e Disbiose – Artigo 15
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson ML, Lee DM, Jarrell DK, Hou S, Ecton KE, Weir TL, Gentile CL. Suppression of gut dysbiosis reverses Western dietinduced vascular dysfunction. Am J Physiol Endocrinol Metab 314: E468–E477, 2018. First published December 26, 2017; doi:10.1152/ ajpendo.00187.2017.—Vascular dysfunction represents a critical preclinical step in the development of cardiovascular disease. We examined the role of the gut microbiota in the development of obesityrelated vascular dysfunction. Male C57BL/6J mice were ...
Nutrição e Disbiose – Artigo 14
Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis
It has been reported that L-arginine is a GLP-1 secretagogue, and that improvement of glucose tolerance by oral
L-arginine administration is dependent on GLP-1R signaling5. Interestingly, in HFD fed mice with severe GLP-1 resistance, glucose-induced insulin secretion was increased by acute and chronic treatment with L-arginine, a substrate of nNOS, suggesting improved GLP-1 sensitivity. These findings raise the intriguing possibility that
L-arginine supplementation might benefit glucose tolerance by ...
Nutrição e Disbiose – Artigo 13
Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome
Abstract
Recent advances in our understanding of how the intestinal microbiome contributes to health and disease have generated great interest in developing strategies for modulating the abundance of microbes and/or their activity to improve overall human health and prevent pathologies such as osteoporosis. Bone is an organ that the gut has long been known to regulate through absorption of calcium, the key bone mineral. However, it is clear that modulation of the gut and its microbiome can affect ...
Nutrição e Disbiose – Artigo 12
Potential role of the intestinal microbiota in programming health and disease
The composition of the microbiota varies according to prenatal events, delivery methods, infant feeding, infant care environment, and antibiotic use. Postnatal gut function and immune development are largely influenced by the intestinal microbiota. Emerging evidence has shown that early microbiota colonization may influence the occurrence of later diseases (microbial programming). The vast majority of microbial species (commensals) give rise to symbiotic host–bacterial interactions that are fundamental ...
Nutrição e Disbiose – Artigo 11
Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases
Background. Microbiota refers to the population of microorganisms (bacteria, viruses and fungi) that inhabit the entire gastrointestinal tract, more particularly the colon whose role is to maintain the integrity of the intestinal mucosa and control the proliferation of pathogenic bacteria. Alteration in the composition of the gut microbiota is called dysbiosis. Dysbiosis redisposes to inflammatory bowel diseases such as ulcerative colitis, Crohn disease and indeter...
Nutrição e Disbiose – Artigo 10
Lack of Vitamin D Receptor Causes Dysbiosisand Changes the Functions of theMurine Intestinal Microbiome
ABSTRACT
Purpose: The microbiome modulates numerous aspects ofhuman physiology and is a crucial factor in the development of various human diseases. Vitamin D deficiency and down regulation of thevitamin D receptor (VDR)are also associated with the patho-genesis of diseases such as inflammatory boweldis-ease, cancers, obesity, diabetes, andasthma.VDR is a nuclear receptor that regulates the expression of antimicrobial peptides and autophagy regulator ATG16L1. Vitamin D may ...
Nutrição e Disbiose – Artigo 9
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease
Adverse fluctuations in the distribution of the intestinal microbiome cohort has been associated with the onset of intra- and extra-intestinal inflammatory conditions, like the metabolic syndrome (MetS) and it’s hepatic manifestation, non-alcoholic fatty liver disease (NAFLD). The intestinalmicrobial community of obese compared to lean subjects has been shown to undergo configurational shifts in various genera, including but not limited to increased abundances of Prevotella, Escherichia, ...
Nutrição e Disbiose – Artigo 8
Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus
murinus in Mice
SUMMARY
Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of dietary biotin per se did not affect skin physiology, its simultaneous treatment with vancomycin resulted in hair loss in specific pathogen-free (SPF) mice. Vancomy...
