Nutrição e Tireoidite de Hashimoto – Artigo 2
Altered expression of CTLA-4, CD28, VDR, and CD45 mRNA in T cells of patients with Hashimoto’s thyroiditis — a pilot study
Abstract
Introduction: CD28/T-cell receptor (TCR)/cytotoxic T-lymphocyte antigen 4 (CTLA4) complex controls T-cell tolerance and autoimmunity in Hashimoto’s thyroiditis (HT). In addition, CD45 protein tyrosine phosphatase (PTPase) and vitamin D receptor (VDR) cooperatively interact with the TCR complex to affect autoimmune processes central to the pathogenesis of HT. Nevertheless, their role in HT aetiology has been less well established. In this study, we ...
Nutrição e Tireoidite de Hashimoto – Artigo 1
25-Hydroxyvitamin D serum level in Hashimoto’s thyroiditis, but not Graves’ disease is relatively deficient
Abstract. Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases(AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serumvitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patientswith hypothyro...
Nutrição e Doença Celíaca – Artigo 20
The Role of Gluten in Celiac Disease and Type 1 Diabetes
Abstract: Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary ...
Nutrição e Doença Celíaca – Artigo 19
The neurologic significance of celiac disease biomarkers
ABSTRACT
Objective: To report neurologic phenotypes and their etiologies determined among 68 patients with either (1) celiac disease (CD) or (2) no CD, but gliadin antibody positivity (2002–2012).
Methods: Neurologic patients included both those with the CD-prerequisite major histocompatibility complex class II human leukocyte antigen (HLA)-DQ2/DQ8 haplotype, and those without. The 3 groups were as follows: group 1 (n 5 44), CD or transglutaminase (Tg)-2/deamidated gliadin immunoglobulin (Ig)A/IgG detected; group 2 (n 5 15), ...
Nutrição e Doença Celíaca – Artigo 18
Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?
Abstract
Background: Recent studies have demonstrated that immune factors might have a role in the pathophysiology of
insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an
important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in
type 1 diabetes mellitus however, there are scarce data about its prevalence in T2DM. Our aim was to investigate
the prevalence of celiac disease ...
Nutrição e Doença Celíaca – Artigo 17
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
Abstract
Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent ...
Nutrição e Doença Celíaca – Artigo 16
Refractory celiac disease and EATL patients show severe malnutrition and malabsorption at diagnosis
Summary Background & aims: Refractory celiac disease type II (RCDII) and EATL (Enteropathy Associated T-cell Lymphoma) are (pre)malignant complications of celiac disease (CD). Data on malnutrition and intestinal absorption is lacking in these patients. Therefore, the aim of the study is to comprehensively assess nutritional status and intestinal absorption capacity of patients with RCDII and EATL, compared with data of newly diagnosed CD patients.
Methods: Observational study in ...
Nutrição e Doença Celíaca – Artigo 15
Pediatric Celiac Disease: Follow-Up in the Spotlight 1,2
ABSTRACT
The follow-up of celiac disease (CD) is challenging due to the scarcity of published data and the lack of standardized evidence-based protocols. The worldwide frequency and methods of CD follow-up appear to be heavily influenced by expert opinions of the individual physicians who assess children with CD. The aim of this review was to summarize the available studies on CD follow-up in children. We conducted a literature search with the use of PubMed, Medline, and Embase (from 1900 to 15 December 2016) for terms relevant ...
