Nutrição e Saúde Mitocondrial – Artigo 11
Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats
Abstract: Evidence indicates that many forms of fructose-induced metabolic disturbance are
associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in metabolic disease resulting from a fructose-rich diet. In the present study, we evaluated the degree of oxidative damage to liver mtDNA and its repair, in addition to the state of oxidative ...
Nutrição e Saúde Mitocondrial – Artigo 10
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
ABSTRACT
Background: Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea and has been considered a natural agent that can help to reduce the risk of obesity.
Objective: The aim of this study was to investigate the effects of EGCG on thermogenesis and
mitochondrial biogenesis in brown adipose tissue (BAT) of diet-induced obese mice.
Methods: Male C57BL/6J mice were provided a high-fat diet for 8 weeks to induce obesity,
following ...
Nutrição e Saúde Mitocondrial – Artigo 9
Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle Cells
ABSTRACT: Mitochondrial biogenesis is a complex process requiring coordinated expression of nuclear and mitochondrial genomes. The peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis, and it controls mitochondrial DNA (mtDNA) replication within diverse tissues, including muscle tissue. The aim of this study was to investigate the effects of eicosapentaenoic acid (EPA) and ...
Nutrição e Saúde Mitocondrial – Artigo 8
Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
Abstract: Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different stages of metabolic demands is the mitochondrion. In this context, mitochondrial dysfunction has been attributed to be the onset and center of many chronic diseases, which are denoted by an inability to adapt fuel preferences and induce mitochondrial morphological changes to ...
Nutrição e Saúde Mitocondrial – Artigo 7
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial
biogenesis in skeletal muscle
Abstract
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members
of the circadian clock and participate in the regulation of a diverse set of metabolic functions.
Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be redundant to REV-ERBα. Recent work has highlighted REVERBα' s role in the regulation of skeletal muscle oxidative capacity and mitochondrial biogenesis. Considering the ...
Nutrição e Saúde Mitocondrial – Artigo 6
Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice
Abstract: Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is
a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve
mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited
evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate ...
Nutrição e Saúde Mitocondrial – Artigo 5
Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet
Abstract: Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease,
certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine is a nontoxic, chemically stable and naturally occurring molecule. This study shows that dietary betaine supplementation significantly inhibits the white fat production in a high-fat diet (HFD)-induced obese mice. This might be due to betaine preventing the formation of new ...
Nutrição e Saúde Mitocondrial – Artigo 4
b-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
b-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. This is mainly achieved by its dual role as structural component of cadherin-based adherens junctions, and as a key nuclear effector of the Wnt pathway. For this dual role, different classes of proteins are differentially regulated via b-catenin dependent mechanisms. Here, we applied a liquid chromatography-mass spectrometry ...
