Nutrição e Síndrome de Cushing – Artigo 9
Síndrome de Cushing: Diagnóstico, Manejo e Avanços na Terapia Personalizada
RESUMO
Este artigo visa revisar o diagnóstico, o manejo e os recentes avanços nas terapias personalizadas para a Síndrome de Cushing, utilizando a base de dados PubMed com os termos "Síndrome de Cushing", "Diagnóstico" e "Tratamento". Os resultados demonstram que a Síndrome de Cushing é uma condição complexa e desafiadora que exige diagnóstico preciso e tratamento adequado para minimizar suas complicações e melhorar a qualidade de vida dos
pacientes. O avanço nas técnicas diagnósticas, como os ...
Nutrição e Síndrome de Cushing – Artigo 8
SÍNDROME DE CUSHING: UMA REVISÃO NARRATIVA
RESUMO
INTRODUÇÃO: A síndrome de Cushing é um conjunto de sinais e sintomas causados pela exposição excessiva a corticoides endógenos ou exógenos, podendo variar entre primária e secundária. A causa mais comum é idiopática, pelo uso desconhecido ou indiscriminado de corticoides, como pela automedicação;
OBJETIVO: Revisão narrativa de artigos referente a fisiopatologia da síndrome de Cushing, para simplificação do
conhecimento e identificação da síndrome e suas repercussões clínicas, mesmo em causas veladas. Além de ...
Nutrição e Síndrome de Cushing – Artigo 7
High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment
Abstract
Objective: Frailty, characterized by multi-system decline, increases vulnerability to adverse health outcomes and can be measured using Frailty Index (FI). We aimed to assess the prevalence of frailty in patients with adrenal disorders (based on hormonal sub-type) and examine association between FI and performance-based measures of physical function.
Design: Multi-centre, cross-sectional study (March 2019-August 2022).
...
Nutrição e Síndrome de Cushing – Artigo 6
Consensus on Diagnosis and Management of Cushing’s Disease: A Guideline Update
Abstract
Cushing’s disease (CD) requires accurate diagnosis, careful treatment selection, and long-term management to optimize patient outcomes. The Pituitary Society convened a Consensus Workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, recent data on screening and diagnosis; surgery, medical and radiation therapy; and disease- and treatment-related complications of CD were ...
Nutrição e Síndrome de Cushing – Artigo 5
Cushing’s disease and bone
Abstract
Bone impairment associated with Cushing’s disease (CD) is a complex disorder, mainly involving deterioration of bone quality and resulting in an increased fracture rate, often despite normal bone mineral density. Bone complications are common in patients with CD at the time of diagnosis but may persist even after successful treatment. There is currently no agreement on the optimal diagnostic methods, thresholds for anti-osteoporotic therapy and its timing in CD. In this review, we summarize the current data on the pathophysiology, diagnostic ...
Nutrição e Síndrome de Cushing – Artigo 4
Glucocorticoid Regulation of Food-Choice Behaviorin Humans: Evidence from Cushing’s Syndrome
The mechanisms by which glucocorticoids regulate food intake and resulting body mass in human sare not well-understood. One potential mechanism could involve modulation of reward processing, but human stress models examining effects of glucocorticoids on behavior contain important confounds. Here, we studied individuals with Cushing’s syndrome, a rare endocrine disorder characterized by chronic excess endogenous glucocorticoids. Twenty-three patients with Cushing’s syndrome (13 with active ...
Nutrição e Síndrome de Cushing – Artigo 3
Very Low-Calorie Ketogenic Diet: A Potential Application in the Treatment of Hypercortisolism Comorbidities
Abstract: A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1–1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing’s syndrome (CS) is characterized by an endogenous or ...
Nutrição e Síndrome de Cushing – Artigo 2
A prospective study of appetite and food craving in 30 patients with Cushing’s disease
Abstract
Context—Glucocorticoid (GC) exposure increases food intake, but the mechanisms in humans are not known. Investigation of appetite and food craving has not been done in patients with chronic GC exposure due to Cushing’s disease (CD), either before or after treatment, and could provide insight into mechanisms of food intake and obesity in these patients.
Purpose—To examine whether surgical remission of CD changes appetite (prospective consumption, hunger, satisfaction, and fullness) and ...
