Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC-1a pathway as a potential mechanism
Abstract
The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC-1a pathway in putative neuroprotection. Wild-type mice were randomly assigned to four groups: the sham group, the TBI
group, the TBI+vehicle group and the TBI+quercetin group. Querce...
Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation
Polyunsaturated fatty acids are important nutrients for human health, especially omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have been found to play positive roles in the prevention of various diseases. However, previous studies have reported that excessive omega-3 fatty acids suppl...
Medium Chain Triglycerides enhances exercise endurance through the increased
mitochondrial biogenesis and metabolism
Abstract
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver
disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic
syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT ...
Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet
Abstract: The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been proposed
to elicit different or even opposite effects, depending on the prevalence of catabolic and ...
Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet
Abstract: The aim of this study was to evaluate the effects of guarana on mitochondrial biogenesis
in a high-fat diet (HFD)-fed mice. C57BL6J mice were divided in two groups: high-fat diet HFD
and high-fat diet + guarana (HFD-GUA). Both groups received HFD and water ad libitum and
the HFD-GUA group also received a daily gavage of guarana (1 g/kg weight). Body weight and
food intake was measured ...
Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats
Abstract: Evidence indicates that many forms of fructose-induced metabolic disturbance are
associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in metabolic disease resulting from a fructose-rich diet. In the present study, we evaluated the ...
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
ABSTRACT
Background: Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea and has been considered a natural agent that can help to reduce the risk of obesity.
Objective: The aim of this study was to investigate the effects of EGCG on thermogenesis and
mitochondrial biogenesis in brown adipose tissue (BAT) of diet-induced obese mice.
...
Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle Cells
ABSTRACT: Mitochondrial biogenesis is a complex process requiring coordinated expression of nuclear and mitochondrial genomes. The peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis, and it controls mitochondrial DNA (mtDNA) replication within diverse tissues, including ...
