Nutrição e Resistência à Leptina – Artigo 9
Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease
Nonstructured Abstract
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in humans. Mechani...
Nutrição e Resistência à Leptina – Artigo 8
Leptin and Obesity: Role and Clinical Implication
Abstract
The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic ...
Nutrição e Resistência à Leptina – Artigo 7
Leptin resistance: underlying mechanisms and diagnosis
Abstract: Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of ...
Nutrição e Resistência à Leptina – Artigo 6
The Leptin System and Diet: A Mini Review of the Current Evidence
Abstract
Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin resistance through dietary interventions can contribute counteracting obesity. Albeit some limitations (e.g., limited rigor, small samples sizes), studies in animals and ...
Nutrição e Resistência à Leptina – Artigo 5
Dietary Components in the Development of Leptin Resistance
ABSTRACT
Classically, leptin resistance has been associated with increased body fat and circulating leptin levels, and the condition is believed to contribute to the onset and/or maintenance of obesity. Although a great deal is known about the central nervous system mechanisms mediating leptin resistance, considerably less is known about the role of diet in establishing and maintaining this altered hormonal state. An exciting new ...
Nutrição e Resistência à Leptina – Artigo 4
Leptin, Obesity, and Leptin Resistance: Where AreWe 25 Years Later?
Abstract: Leptin, a hormone that is capable of eectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic eects in obese individuals, and therefore, the lack of clinical ...
Nutrição e Resistência à Leptina – Artigo 3
Leptin signaling and leptin resistance
Abstract: With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that
regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors (LepR) in the brain. The failure of increased leptin levels to suppress feeding and elevate energy expenditure is ...
Nutrição e Resistência à Leptina – Artigo 2
O papel dos hormônios leptina e grelina na gênese da obesidade
R E S U M O
A prevalência da obesidade está aumentando e estudos prospectivos mostram que, em 2025, o Brasil será o quinto país do mundo a apresentar problemas de obesidade em sua população. A etiologia da obesidade não é de fácil identificação, uma vez que a mesma é caracterizada como uma doença multifatorial, ou seja, diversos fatores estão envolvidos em sua gênese, incluindo fatores genéticos, psicológicos, ...
