Nutrição e sistema imunológico – Artigo 04
Effect of n-3 fatty acids on the expression
of inflammatory genes in THP-1
macrophages
Background: Uncontrolled inflammation participates in the development of inflammatory diseases. Beneficial effects of polyunsaturated fatty acids belonging to the n-3 family such as eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) on inflammation have been reported.
The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Β, MCP1, ALOX5, PTGS2, MGST1and NOS2) related to inflammation in unstimulated cul...
Nutrição e Depressão – Artigo 12
Omega-3 Fatty Acids, Depressive Symptoms, and Cognitive
Performance in Patients With Coronary Artery Disease
Abstract: This trial investigated the efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment for improving depressive symptoms and cognitive performance in patients with coronary artery disease (CAD) participating in cardiac rehabilitation. Patients with CAD aged 45 to 80 years were randomized to receive either 1.9-g/d n-3 PUFA treatment or placebo for 12 weeks. Depressive symptoms were measured using the Hamilton Depression Rating Scale (HAM-D, primary outcome) ...
