A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in
SLC30A8
Background: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by the SLC30A8 genotype.
Results: We carried out a prospective study among subjects with no history cardio-metabolic ...
