Ações do Zinco na Saúde Humana – Artigo 20
Zinc, aging, and immunosenescence: an overview
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence. Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.
Ações do Zinco na Saúde Humana – Artigo 6
Roles of Zinc Signaling in the Immune System
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth, differentiation, and survival. Zn deficiency depresses both innate and adaptive immune responses. However, the precise physiological mechanisms of the Zn-mediated regulation of the immune system have been largely unclear. Zn homeostasis is tightly controlled by the coordinated activity of Zn transporters and metallothioneins, which regulate the transport, distribution, and storage of Zn. There is growing evidence that Zn behaves like a signaling molecule, ...
Ações do Zinco na Saúde Humana – Artigo 11
Zinc in Infection and Inflammation
Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an essential micronutrient that is involved in the regulation of the innate and adaptive immune responses. The main cause of zinc deficiency is malnutrition. Zinc deficiency leads to cell-mediated immune dysfunctions among other manifestations. Consequently, such dysfunctions lead to a worse outcome in the response towards bacterial infection and sepsis. For instance, zinc is an essential component of the pathogen-eliminating signal transduction pathways leading to ...
Ações do Zinco na Saúde Humana – Artigo 3
Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis
Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism. It may also have a protective role in the prevention of atherogenesis. Numerous studies have evaluated the effects of Zinc supplementation on serum lipids in humans and have demonstrated varying results. We systematically evaluated the literature and performed a meta-analysis on the effects of Zinc supplementation on serum lipids. A five staged comprehensive ...
Ações do Zinco na Saúde Humana – Artigo 1
A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in
SLC30A8
Background: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by the SLC30A8 genotype.
Results: We carried out a prospective study among subjects with no history cardio-metabolic ...
Ações do Zinco na Saúde Humana – Artigo 7
Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer’s Disease: A Meta-Analysis of Case-Control Studies
Background: Many publications have investigated the association between metal ions
and the risk of Alzheimer’s disease (AD), but the results were ambiguous.
Aims: The objective of this study was to assess the association between the serum
levels of metals (copper/zinc/iron) and the risk of AD via meta-analysis of case-control studies.
Methods: We screened literatures published after 1978 in the Pubmed, Embase,
Cochrane library, Web of Science and ClinicalTrials.gov. ...
Ações do Zinco na Saúde Humana – Artigo 13
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be ...
Ações do Zinco na Saúde Humana – Artigo 16
Zinc Signal in Brain Diseases
The divalent cation zinc is an integral requirement for optimal cellular processes, whereby it contributes to the function of over 300 enzymes, regulates intracellular signal transduction, and contributes to efficient synaptic transmission in the central nervous system. Given the critical role of zinc in a breadth of cellular processes, its cellular distribution and local tissue level concentrations remain tightly regulated
via a series of proteins, primarily including zinc transporter and zinc import proteins. A loss of function of these regulatory pathways, ...
