Nutrição e Saúde Mitocondrial – Artigo 4
b-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
b-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. This is mainly achieved by its dual role as structural component of cadherin-based adherens junctions, and as a key nuclear effector of the Wnt pathway. For this dual role, different classes of proteins are differentially regulated via b-catenin dependent mechanisms. Here, we applied a liquid chromatography-mass spectrometry ...
Nutrição e Saúde Mitocondrial – Artigo 3
Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
Apples are well known to have various benefits for the human body. Procyanidins are a class of
polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal
organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of proteoglycan homeostasis in chondrocytes. However, no useful therapy for cartilage degeneration has been developed to date. In the present study, ...
Nutrição e Saúde Mitocondrial – Artigo 2
Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice
Abstract: Panax ginseng C. A. Meyer (ginseng) is an edible and medicinal Chinese herb, which
is often used in Asian countries for physical fitness. Ginseng is reported to have a wide range
of biological activity and pharmaceutical properties. There were more studies on ginsenosides
and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule
oligopeptides isolated from ginseng. The present study was designed to evaluate the anti-fatigue
effects of ...
Nutrição e Saúde Mitocondrial – Artigo 1
A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders
Abstract: In human cells, mitochondria provide the largest part of cellular energy in the form
of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS).
Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential innovative strategies aim to ameliorate mitochondrial function by increasing the total mitochondrial load of tissues and/or to scavenge the ...
