Nutrição e Disbiose – Artigo 11
Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases
Background. Microbiota refers to the population of microorganisms (bacteria, viruses and fungi) that inhabit the entire gastrointestinal tract, more particularly the colon whose role is to maintain the integrity of the intestinal mucosa and control the proliferation of pathogenic bacteria. Alteration in the composition of the gut microbiota is called dysbiosis. Dysbiosis redisposes to inflammatory bowel diseases such as ulcerative colitis, Crohn disease and indeter...
Nutrição e Disbiose – Artigo 10
Lack of Vitamin D Receptor Causes Dysbiosisand Changes the Functions of theMurine Intestinal Microbiome
ABSTRACT
Purpose: The microbiome modulates numerous aspects ofhuman physiology and is a crucial factor in the development of various human diseases. Vitamin D deficiency and down regulation of thevitamin D receptor (VDR)are also associated with the patho-genesis of diseases such as inflammatory boweldis-ease, cancers, obesity, diabetes, andasthma.VDR is a nuclear receptor that regulates the expression of antimicrobial peptides and autophagy regulator ATG16L1. Vitamin D may ...
Nutrição e Disbiose – Artigo 9
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease
Adverse fluctuations in the distribution of the intestinal microbiome cohort has been associated with the onset of intra- and extra-intestinal inflammatory conditions, like the metabolic syndrome (MetS) and it’s hepatic manifestation, non-alcoholic fatty liver disease (NAFLD). The intestinalmicrobial community of obese compared to lean subjects has been shown to undergo configurational shifts in various genera, including but not limited to increased abundances of Prevotella, Escherichia, ...
Nutrição e Disbiose – Artigo 8
Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus
murinus in Mice
SUMMARY
Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of dietary biotin per se did not affect skin physiology, its simultaneous treatment with vancomycin resulted in hair loss in specific pathogen-free (SPF) mice. Vancomy...
Nutrição e Disbiose – Artigo 7
Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Summary
The distal gut harbours ∼1013 bacteria, representing the most densely populated ecosystem known. The functional diversity expressed by these communities is enormous and relatively unexplored. The past decade of research has unveiled the profound influence that the resident microbial populations bestow to host immunity and metabolism. The evolution of these communities from birth generates a highly adapted and highly personalized microbiota that is stable in healthy individuals. Immune homeost...
Nutrição e Disbiose – Artigo 6
Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review
In the present world scenario, obesity has almost attained the level of a pandemic and is progressing at a rapid rate. This disease is the mother of all other metabolic disorders, which apart from placing an added financial burden on the concerned patient also has a negative impact on his/her well-being and health in the society.
Among the various plausible factors for the development of obesity, the role of gut microbiota is very crucial. In general, the gut of an individual ...
Nutrição e Disbiose – Artigo 5
Dysbiotic drift and biopsychosocial medicine: how the microbiome links personal, public and planetary health
Abstract
The emerging concept of planetary health emphasizes that the health of human civilization is intricately connected to the health of natural systems within the Earth’s biosphere; here, we focus on the rapidly progressing microbiome science - the microbiota-mental health research in particular - as a way to illustrate the pathways by which exposure to biodiversity supports health. Microbiome science is illuminating the ways in which stress,
socioeconomic disadvantage ...
Nutrição e Disbiose – Artigo 4
Dysbiosis in Functional Bowel Disorders
Abstract
Functional bowel disorders (FBD) resemble a group of diseases of the gastrointestinal (GI) tract that are without a clear pathogenesis; the best known is probably the “irritable bowel syndrome” (IBS). Only recently we have been able to explore the role of the gut microbiota in FBD due to progress in microbiological analytic techniques. There are different ways to explore the role of the gut microbiota and its dysbiosis in FBD. Comparison of the microbial composition in a group of patients with FBD, for example, with IBS to a ...
