Nutrição e Doença de Cron – Artigo 20
Vitamin D increases programmed death receptor-1 expression in Crohn’s disease
ABSTRACT
Background: Vitamin D modulates inflammation in Crohn’s disease (CD). Programmed death (PD)-1 receptor contributes to the maintenance of immune tolerance. Vitamin D might modulate PD-1 signalling in CD.
Aim: To investigate PD-1 expression on T cell subsets in CD patients treated with vitamin D or placebo.
Methods: We included 40 CD patients who received 1200 IU vitamin D3 for 26 weeks or placebo and eight healthy controls. Peripheral blood mononuclear cells (PBMCs) and plasma were isolated ...
Nutrição e Doença de Cron – Artigo 19
Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium
Concentrations and Increased Cardiovascular Risk
Abstract: The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn’s disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in ...
Nutrição e Doença de Cron – Artigo 18
The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review
Abstract: Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbio...
Nutrição e Doença de Cron – Artigo 17
The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients
in Canada
Abstract: We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the ...
Nutrição e Doença de Cron – Artigo 15
Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study
Summary
Background—Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown.
Methods—We did a prospective inception cohort study of paediatric patients with newly diagnosed Crohn’s disease at 28 sites in the USA and Canada. Genotypes, antimicr...
Nutrição e Doença de Cron – Artigo 16
Systematic Review with Meta-Analysis: Enteral Nutrition Therapy for the Induction of Remission in Pediatric Crohn’s Disease
Abstract
Background—Despite potential adverse-events in a pediatric population, corticosteroids (CS) are used to induce remission in pediatric Crohn’s disease. Exclusive enteral nutrition (EEN) also induces remission, but is infrequently used in the United States because CS is considered the superior therapy. New data have become available since the publication of the most recent metaanalysis in 2007.
Methods—All studies with comparator arms of EEN and ...
Nutrição e Doença de Cron – Artigo 14
Preoperative Nutritional Conditioning of Crohn’s Patients—Systematic Review of Current Evidence
and Practice
Abstract: Crohn’s disease is an incurable and frequently progressive entity with major impact on affected patients. Up to half of patients require surgery in the first 10 years after diagnosis and over 75% of operated patients require at least one further surgery within lifetime. In order to minimize surgical risk, modifiable risk factors such as nutritional status need to be optimized. This systematic review on preoperative nutritional support in adult Crohn’s ...
Nutrição e Doença de Cron – Artigo 13
Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease
Abstract: Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a ...
