Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 4
Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis
Abstract
IMPORTANCE—There is growing interest in the role of nutrition in the pathogenesis and
progression of amyotrophic lateral sclerosis (ALS).
OBJECTIVE—To evaluate the associations between nutrients, individually and in groups, and
ALS function and respiratory function at diagnosis.
DESIGN, SETTING, AND PARTICIPANTS—A cross-sectional baseline analysis of the
Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 3
Assessment and nutrition education in patients with amyotrophic lateral sclerosis
Avaliação e educação nutricional em pacientes com esclerose lateral amiotrófica
RESUMO
Pacientes neurológicos com esclerose lateral amiotrófica frequentemente evoluem com piora do estado nutricional. O objetivo desse estudo foi comparar o estado nutricional e a ingestão alimentar depois da orientação nutricional em pacientes com ELA. Variáveis clínicas, antropométricas e funcionais foram analisadas. 53 pacientes foram avaliados na fase inicial da doença. A pontuação média da escala de ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 2
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways
Abstract: Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the noninflammatory patients (n = 7) into another subset with a B cell signature. The inflammatory subset was remarkable for granulocyte and agranulocyte diapedesis, hepatic fibrosis, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 1
A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy
Abstract
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS oxidative stress clouds corresponding conclusions. Therefore, we construct a comprehensive, temporal view of oxidative stress and corresponding antioxidant ...
