Nutrição e Doença de Cron – Artigo 18
The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review
Abstract: Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbio...
Nutrição e Doença de Cron – Artigo 17
The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients
in Canada
Abstract: We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the ...
Nutrição e Doença de Cron – Artigo 15
Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study
Summary
Background—Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown.
Methods—We did a prospective inception cohort study of paediatric patients with newly diagnosed Crohn’s disease at 28 sites in the USA and Canada. Genotypes, antimicr...
Nutrição e Doença de Cron – Artigo 16
Systematic Review with Meta-Analysis: Enteral Nutrition Therapy for the Induction of Remission in Pediatric Crohn’s Disease
Abstract
Background—Despite potential adverse-events in a pediatric population, corticosteroids (CS) are used to induce remission in pediatric Crohn’s disease. Exclusive enteral nutrition (EEN) also induces remission, but is infrequently used in the United States because CS is considered the superior therapy. New data have become available since the publication of the most recent metaanalysis in 2007.
Methods—All studies with comparator arms of EEN and ...
Nutrição e Doença de Cron – Artigo 14
Preoperative Nutritional Conditioning of Crohn’s Patients—Systematic Review of Current Evidence
and Practice
Abstract: Crohn’s disease is an incurable and frequently progressive entity with major impact on affected patients. Up to half of patients require surgery in the first 10 years after diagnosis and over 75% of operated patients require at least one further surgery within lifetime. In order to minimize surgical risk, modifiable risk factors such as nutritional status need to be optimized. This systematic review on preoperative nutritional support in adult Crohn’s ...
Nutrição e Doença de Cron – Artigo 13
Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease
Abstract: Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a ...
Nutrição e Doença de Cron – Artigo 12
Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn’s Disease
Abstract: MicroRNAs (miRNAs) have been shown to be important for the pathogenesis of Crohn’s disease (CD). Exclusive enteral nutrition (EEN) is an effective therapy for inducing remission in CD. We aimed to investigate the alteration of miRNAs expression profile in the terminal ileal mucosa of CD patients before and after EEN. Twenty-five patients and ten healthy individuals were included. MiRNAs expression profile was firstly assessed using microarray ...
Nutrição e Doença de Cron – Artigo 11
Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response
Meta-Analysis of Epidemiological Studies
Abstract: Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to identify all relevant studies, and the role of macronutrients in the development of CD was quantitatively assessed by dose–response meta-analysis. ...
