Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 24
NF‑κB, inflammation, immunity and cancer: coming of age
Abstract | Fourteen years have passed since nuclear factor‑κB (NF‑κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF‑κB in linking inflammation and cancer led to an improved understanding of tumour-elicited ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 23
Early Life Stress, Air Pollution, Inflammation, and Disease: An Integrative Review and Immunologic Model of SocialEnvironmental Adversity and Lifespan Health
Abstract
Socially disadvantaged individuals are at greater risk for simultaneously being exposed to adverse social and environmental conditions. Although the mechanisms underlying joint effects remain unclear, one hypothesis is that toxic social and environmental exposures have synergistic effects on inflammatory processes that underlie the development of chronic diseases, including cardiovascular disease, diabetes, depression, and ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 22
The Contribution of Inflammation to the Development of Hypertension Mediated by Increased Arterial Stiffness
Background-—The mechanisms underlying the possible contribution of chronic inflammation to the development of hypertension remain unclear. We examined the longitudinal association of inflammation with the progression of vascular and/or renal abnormalities in the development of hypertension.
Methods and Results-—In 3274 middle-aged Japanese men without hypertension at the study baseline, brachial-ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 21
The multiple pathways to autoimmunity
Efforts to understand autoimmunity have been pursued relentlessly for several decades. It has become apparent that the immune system evolved multiple mechanisms for controlling self-reactivity, and defects in one or more of these mechanisms can lead to a breakdown of tolerance. Among the multitude of lesions associated with disease, the most common seem to affect peripheral tolerance rather than central tolerance. The initial trigger for both systemic autoimmune disorders and organ-specific autoimmune disorders probably involves the recognition of self ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 20
Biochemical and cellular properties of insulin receptor signalling
Abstract | The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β‑cells, genetic and acquired abnormalities of insulin action underlie the far more common conditions of type 2 diabetes, obesity and insulin resistance. The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. Hence, understanding the biochemical and cellular properties of insulin receptor ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 19
The immunology of atherosclerosis
Abstract | Cardiovascular disease is the leading cause of death worldwide, both in the general population and among patients with chronic kidney disease (CKD). In most cases, the underlying cause of the cardiovascular event is atherosclerosis — a chronic inflammatory disease. CKD accelerates atherosclerosis via augmentation of inflammation, perturbation of lipid metabolism, and other mechanisms. In the artery wall, subendothelial retention of plasma lipoproteins triggers monocyte-derived macrophages and T helper type 1 (TH1) cells to form atherosclerotic ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 18
O papel da inflamação na sarcopenia relacionada à idade
Muitas mudanças fisiológicas ocorrem com o envelhecimento. Essas mudanças frequentemente, direta ou indiretamente, resultam em uma deterioração da qualidade de vida e até em uma redução da expectativa de vida. Além dos níveis aumentados de espécies reativas de oxigênio, dano ao DNA e apoptose celular, outro fator importante que afeta o processo de envelhecimento envolve uma inflamação sistêmica crônica de baixo grau. Esta condição já demonstrou estar inter-relacionada com várias condições (sub) clínicas, ...
Alimentando Práticas – Inflamação Metabólica – Daniel Barreto – artigo 17
Obesity, Diabetes, and Cardiovascular Diseases Compendium
Abstract: Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence
indicates that cardiovascular disease is the collateral damage of obesity-driven adipose tissue dysfunction that
promotes a chronic inflammatory state within the organism. Adipose tissues secrete bioactive substances, referred
to as adipokines, which largely function as modulators of inflammation. The microenvironment of adipose tissue
will affect the adipokine secretome, having actions on remote tissues. Obesity typica...
