Higher than Normal Plasma Iinterleukin-6 Concentrations in Brazilian Patients with Mood Disorders
ABSTRACT
The aim of this work was to study the plasma concentration of IL-6 by ELISA in the patients with mood disorders
and normal healthy donors. The plasma concentration of IL-6 was higher in the patients than in the control healthy
group. Results suggested that IL-6 could serve as an immunological marker in mood disorder pathogenesis as well.
Key words: IL-6, cytokines, mood disorder
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression
ABSTRACT
Background: The intake of glucose or a high-fat, high-carbohydrate (HFHC) meal, but not orange juice, induces an increase in inflammation and oxidative stress in circulating mononuclear cells (MNCs) of normal-weight subjects.
Objective: We investigated the effect of orange juice on HFHC meal–induced inflammation and oxidative stress and the expression of plasma endotoxin and Toll-like receptors (TLRs).
Design: Three groups ...
Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
OBJECTIVE — We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to ...
Sleep Duration and All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies
Background: Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes.
Objectives: To assess whether the population longitudinal evidence supports the presence of a relationship between duration of sleep and allcause mortality, to investigate both short and long sleep duration and to obtain an estimate of the risk.
Methods: We performed a systematic search of publications using MEDLINE (1966-2009), EMBASE (from 1980), ...
Mechanisms of Disease: oxidative stress and inflammation in the pathogenesis of hypertension
SUMMARY
Animal studies have shown that oxidative stress and renal tubulointerstitial inflammation are associated with, and have major roles in, the pathogenesis of hypertension. This view is supported by the observations that alleviation of oxidative stress and renal tubulointerstitial inflammation reduce arterial pressure in animal models. Conversely,
hypertension has been shown to cause oxidative stress and inflammation in renal and cardiovascular tissues in experimental animals. Taken ...
Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength
ABSTRACT
PURPOSE: The objective of this study was to investigate whether high levels of serum interleukin (IL)-6, C-reactive protein (CRP), and 1-antichymotrypsin (ACT) were associated with the loss of muscle strength or muscle mass (sarcopenia) in older persons.
SUBJECTS: The study included 986 men and women of the Longitudinal Aging Study Amsterdam, with a mean age of 74.6 years (standard deviation 6.2).
METHODS: Grip strength (n 986) and appendicular muscle mass (n 328, using dual-energy x-ray absorptiometry) ...
The anti-inflammatory effect of exercise
Petersen, Anne Marie W., and Bente Klarlund Pedersen. The anti-inflammatory effect of exercise. J Appl Physiol 98: 1154 –1162, 2005; doi:10.1152/japplphysiol. 00164.2004.—Regular exercise offers protection against all-cause mortality, primarily by protection against cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated with chronic low-grade systemic inflammation reflected by a two- to threefold elevated level of several cytokines. Adipose tissue contributes to the production of TNF-, which is reflected ...
C-Reactive Protein Levels and Outcomes after Statin Therapy
Abstract
Background
Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP). Whether this latter property affects clinical outcomes is unknown.
Methods
We evaluated relationships between the LDL cholesterol and CRP levels achieved after treatment with 80 mg of atorvastatin or 40 mg of pravastatin per day and the risk of recurrent myocardial infarction or death from coronary causes among 3745 patients with acute coronary syndromes.
Results
Patients in whom statin therapy resulted ...
