The Relationship between Obesity and Clinical Outcomes in Young People with Duchenne Muscular Dystrophy
Abstract: Background: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder. Young people withDMDhave high rates of obesity. There is emerging evidence that a higher BMI may negatively affect clinical outcomes in DMD. This study aimed to explore the relationship between obesity and clinical outcomes in DMD.
Methods: ...
When dysbiosis meets dystrophy: an unwanted gut-muscle connection
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular degenerative disease with no known cure to date. In recent years, the hypothesis of a “gutmuscle axis” has emerged suggesting that bidirectional communication between the gut microbiota and the muscular system regulates the muscular function and may be perturbed in several muscular disorders. In addition, the ...
A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy
A b s t r a c t
We conducted a systematic literature review and meta-analysis on the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in Duchenne muscular dystrophy. Due to a lack of randomised controlled trials, cross-sectional and retrospective and prospect...
Frequency of Delayed Puberty in Boys with Contemporary Management of Duchenne Muscular Dystrophy
Abstract
Background: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy (DMD) treated with long term oral glucocorticoid. This study aims to report the frequency of delayed puberty in DMD from examination by a paediatric endocrinologist alongside detailed endocrine investigations.
Methods: All boys with DMD aged at ...
Nutritional Issues among Children with Duchenne Muscular Dystrophy—Incidence of Deficiency and Excess Body Mass
Abstract: The progression of Duchenne muscular dystrophy (DMD)requires the assessment of nutritional disturbances at each stage of the disease. The purpose of this study was to assess the nutritional status in various ages of boys with DMD using screening and in-depth evaluation methods. Body composition by Dual X-ray Absorptiom...
Duchenne muscular dystrophy
Abstract
Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads to difficulties with movement and, eventually, to the need for assisted ventilation and premature death. The disease is caused by mutations in DMD (encoding dystrophin) that abolish the production of dystrophin in muscle. Muscles without dystrophin are more sensitive to damage, resulting in progressive loss of muscle ...
Distrofia muscular de Duchenne: uma revisão narrativa
RESUMO
A Distrofia Muscular de Duchenne (DMD) é uma condição genética progressiva e heterogênea, caracterizada primordialmente pela degradação da força muscular, resultando em incapacidade de locomoção e, eventualmente, comprometimento dos músculos respiratórios e cardíacos. Conhecida pela sua ligação ao cromossomo X, afeta majoritariamente indivíduos do sexo masculino e ...
Recomendações nutricionais na Distrofia Muscular de Duchenne
RESUMO
OBJETIVO: Pesquisar as recomendações nutricionais para pacientes com Distrofia Muscular de Duchenne (DMD).
MÉTODO: Trata- se de uma revisão integrativa da literatura, através de levantamento bibliográfico nas bases cientificas PubMed e Scielo, foram utilizadas as palavras chaves: Distrofia Muscular de Duchenne em combinação com os termos Nutrição, Nutrientes, ...
