Hiper-homocisteinemia e risco cardiometabólico
RESUMO
A hiper-homocisteinemia, quando considerada como fator causal de doenças vasculares, tem suscitado muitas discussões. Estudos caso-controle, retrospectivos e prospectivos têm identificado relação entre concentrações plasmáticas elevadas de homocisteÃna e doenças vasculares. Na presente revisão, objetivou-se compreender melhor a inter-relação entre as concentrações plasmÃ...
The Treatment of Hyperhomocysteinemia
Abstract
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects, and a tendency to promote oxidant stress-induced cellular toxicity. Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular disease, dementia-type disorders, and osteoporosis...
Lowering homocysteine and modifying nutritional status with folic acid and vitamin B12 in Indian patients of vascular disease
Abstract
Hyperhomocysteinemia is more commonly associated with vascular disease in Indians than in the western populations. It is caused by genetic polymorphisms or dietary deficiencies of the B vitamins. We attempted to identify the association of hyperhomocysteinemia with vitamin B12 and folate in Indian patients of ...
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
Abstract
Hyperhomocysteinemia is recognized as a risk factor for several diseases, including cardiovascular and neurological conditions. Homocysteine (HCys) is a key metabolite involved in the biosynthesis andmetabolismofmethionine (Met),which plays a pivotal role in the physiological cell’s life cycle. The biochemistry of Met is finely ...
Influence of Dietary Supplementation for Hyperhomocysteinemia Treatments
Abstract: Hyperhomocysteinemia is recognized as risk factor for cardiovascular and age-associated diseases. Folic acid supplementation eciently lowers plasma homocysteine (Hcy) levels, but high intake may negatively aect health because of unnatural levels of unmetabolized folic acid in the systemic circulation. Oxoproline (Oxo) provides by glutamic acid production an ...
The metabolism and significance of homocysteine in nutrition and health
Abstract
An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur
containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was
subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer’s disease, Parkinson’s disease, stroke, and ...
