Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions
Abstract: A growing number of preclinical and human studies demonstrate a disease-modifying effect of nutritional state in amyotrophic lateral sclerosis (ALS). The management of optimal nutrition in ALS is complicated, as physiological, physical, and psychological effects of the disease need to be considered and addressed ...
Enteral feeding through endoscopic gastrostomy in amyotrophic lateral sclerosis
patients
Nutrición enteral por gastrostomía endoscópica en pacientes con esclerosis lateral amiotrófica
Resumen
Introducción: la disfagia es común en pacientes con esclerosis lateral amiotrófi ca (ELA) y pude resultar en desnutrición. Se recomienda la gastrostomía endoscópica (PEG) cuando la alimentación oral no es más segura. Este trabajo tiene ...
Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis
Abstract: In this review, we summarize the most important recent developments in the
treatment of amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment
options, several drugs such as dexpramipexole, pioglitazone, lithium, and many others have been tested in large multicenter trials, albeit with disappointing results. Therefore, riluzole ...
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention
Summary
In mutant SOD1 transgenic mouse models, a high‑caloric, high‑fat diet or ketogenic diet generally had protective effects on ALS; however, in the mouse models, the pathogenesis is mainly associated with oxidative stress. The effect of energy intake and diets on other ALS mechanisms should be further investigated. On the other ...
Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis
Abstract
Background: Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal ...
Dietary intake and zinc status in amyotrophic lateral sclerosis patients
Ingesta dietética y estado de zinc en pacientes con esclerosis lateral amiotrófica
Resumen
Introducción: hay pruebas considerables de que los cambios en la homeostasis del zinc están relacionados con la patogénesis de la esclerosis lateral amiotrófica (ELA) y que la malnutrición es un factor pronóstico capaz de reducir la supervivencia de los pacientes con ...
Complementary and Alternative Therapies in ALS
Synopsis
Given the severity of their illness and lack of effective disease modifying agents, it is not
surprising that most patients with ALS consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and energy healing. This chapter reviews these in det...
Blood Levels of Trace Metals and Amyotrophic Lateral Sclerosis
Abstract
Some trace metals may increase risk of amyotrophic lateral sclerosis (ALS), whereas others may
be beneficial. Our goal was to examine associations of ALS with blood levels of selenium (Se),
zinc (Zn), copper (Cu), and manganese (Mn). We conducted a case-control study of 163
neurologist confirmed patients from the National Registry of Veterans with ALS and 229
frequ...
