Complementary and Alternative Therapies in ALS
Synopsis
Given the severity of their illness and lack of effective disease modifying agents, it is not
surprising that most patients with ALS consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and energy healing. This chapter reviews these in det...
Blood Levels of Trace Metals and Amyotrophic Lateral Sclerosis
Abstract
Some trace metals may increase risk of amyotrophic lateral sclerosis (ALS), whereas others may
be beneficial. Our goal was to examine associations of ALS with blood levels of selenium (Se),
zinc (Zn), copper (Cu), and manganese (Mn). We conducted a case-control study of 163
neurologist confirmed patients from the National Registry of Veterans with ALS and 229
frequ...
Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival
Abstract Background: There are inconsistences regarding the correlation between diabetes or fasting blood glucose concentrations and the risk and survival of amyotrophic lateral sclerosis (ALS) in the previous studies. Moreover, the association between hemoglobin A1c (HbA1c) levels, which reflect long-term glycemic status, and ALS survival was not examined. Methods: A ...
Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis
Abstract
IMPORTANCE—There is growing interest in the role of nutrition in the pathogenesis and
progression of amyotrophic lateral sclerosis (ALS).
OBJECTIVE—To evaluate the associations between nutrients, individually and in groups, and
ALS function and respiratory function at diagnosis.
DESIGN, SETTING, AND PARTICIPANTS—A cross-sectional baseline ...
Assessment and nutrition education in patients with amyotrophic lateral sclerosis
Avaliação e educação nutricional em pacientes com esclerose lateral amiotrófica
RESUMO
Pacientes neurológicos com esclerose lateral amiotrófica frequentemente evoluem com piora do estado nutricional. O objetivo desse estudo foi comparar o estado nutricional e a ingestão alimentar depois da orientação nutricional em pacientes com ELA. Variáveis...
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways
Abstract: Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the noninflammatory patients (n = 7) ...
A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy
Abstract
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS ...
Identifcation of candidate genes associated with fbromyalgia susceptibility in southern Spanish women: the al‑Ándalus project
Abstract
Background: Candidate-gene studies on fbromyalgia susceptibility often include a small number of single nucleo‑ tide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefore, we compared genotype frequencies of candidate SNPs in a well-characterised ...
