Nutrição e Envelhecimento – Artigo 13

Proteostasis, oxidative stress and aging ABSTRACT The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are necessary which regulate and preserve a functional cellular protein pool, in a process termed “proteostasis”. Not only the mammalian ...

Nutrição e Envelhecimento – Artigo 12

Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease  ABSTRACT A projected doubling in the global population of people aged $60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, ...

Nutrição e Envelhecimento – Artigo 11

Nutrition and other Lifestyle Influences on Arterial Aging Abstract As our world’s population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial function. Accumulating evidence demonstrates that diet and ...

Nutrição e Envelhecimento – Artigo 10

Nutrition and lifestyle in healthy aging: the telomerase challenge Abstract: Nutrition and lifestyle, known to modulate aging process and age‐related diseases, might also affect telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation ...

Nutrição e Envelhecimento – Artigo 9

Nutrients, Microglia Aging, and Brain Aging As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce ...

Nutrição e Envelhecimento – Artigo 8

MITOCHONDRIAL FUNCTION IN HYPOXIC ISCHEMIC INJURY AND INFLUENCE OF AGING Abstract Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment increases with age leading to dysregulation of molecular pathways linked to mitochondria. The perturbation of mitochondrial homeostasis and cellular energetics worsens outcome following hypoxicischemic insults in elderly individuals. In response to acute injury conditions, ...

Nutrição e Envelhecimento – Artigo 7

mTOR as regulator of lifespan, aging and cellular senescence Abstract The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling hub that senses and integrates environmental and intracellular nutrient and growth factor signals to coordinate basic cellular and organismal responses such as cell growth, proliferation, apoptosis, and inflammation dependent on the individual cell and tissue. A growing list of ...

Nutrição e Envelhecimento – Artigo 6

Impaired Vestibular Function and Low Bone Mineral Density: Data from the Baltimore Longitudinal Study of Aging ABSTRACT Animal studies have demonstrated that experimentally induced vestibular ablation leads to a decrease in bone mineral density, through mechanisms mediated by the sympathetic nervous system. Loss of bone mineral density is a common and potentially morbid condition that occurs with aging, and we sought to investigate ...