Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis
Purpose. To explore the possible role of MIF and Th17 cells in the thyroid-specific autoimmune damage of Hashimoto’s thyroiditis (HT). Material and Methods. We enrolled 40 HT patients and 30 healthy controls and divided HT patients into euthyroid subset ( = 22) and subclinical or overt ...
Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis
Abstract
OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients who ...
Is vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis?
Abstract
Objective: The aim of this study was to investigate vitamin D status by measuring serum 25(OH)D levels in euthyroid patients with Hashimoto's thyroiditis (HT) who lived and worked on the sunny island of Crete, Greece, and to evaluate whether vitamin D3 supplementation is benecial for the management of HT patients with vitamin D deciency. Subjects and ...
Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children
ABSTRACT
Objective: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children. Materials and Methods: ...
Hashimoto's Thyroiditis: From Genes to the Disease
Abstract: Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Intrathyroidal lymphocytic infiltration is followed by a gradual destruction of the thyroid gland which may lead to subclinical or overt hypothyroidism. Biochemical markers of the disease are thyroid peroxidase and/or thyroglobulin autoantibodies in the serum which are present with a higher preval...
Evaluation of Xerostomia and salivary flow rate in Hashimoto’s Thyroiditis
Abstract
Background: One of the most common causes of hypothyroidism is Hashimoto´s Thyroiditis (HT). Early detection
of dry mouth is critical in preserving and promoting systemic and oral health. In this study we have assessed, for the first time, salivary function and xerostomia in HT patients who have not been involved with Sjögren´s syndrome.
Material ...
Association between Hashimoto’s thyroiditis and cholelithiasis: a retrospective cohort study in Taiwan
Abstract
Objective To investigate the relation of Hashimoto’s thyroiditis (HT) to cholelithiasis and cholecystectomy in a
retrospective population-based study. Setting Cohort study. Participants We identified 1268 patients aged ≥20 years
with HT between 2000 and 2010 as the study cohort.
Primary and secondary outcome measures ...
Altered expression of CTLA-4, CD28, VDR, and CD45 mRNA in T cells of patients with Hashimoto’s thyroiditis — a pilot study
Abstract
Introduction: CD28/T-cell receptor (TCR)/cytotoxic T-lymphocyte antigen 4 (CTLA4) complex controls T-cell tolerance and autoimmunity in Hashimoto’s thyroiditis (HT). In addition, CD45 protein tyrosine phosphatase (PTPase) and vitamin D receptor (VDR) cooperatively interact with the TCR complex to ...
