Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle Cells
ABSTRACT: Mitochondrial biogenesis is a complex process requiring coordinated expression of nuclear and mitochondrial genomes. The peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis, and it controls mitochondrial DNA (mtDNA) ...
Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
Abstract: Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different stages of metabolic demands is the mitochondrion. In this context, mitochondrial dysfunction has been attributed to be the ...
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial
biogenesis in skeletal muscle
Abstract
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members
of the circadian clock and participate in the regulation of a diverse set of metabolic functions.
Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be redundant to REV-ERBα. ...
Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice
Abstract: Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is
a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve
mitochondrial biogenesis and adenosine triphosphate (ATP) production. ...
Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet
Abstract: Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease,
certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine is a nontoxic, chemically stable and naturally occurring molecule. This study shows that dietary betaine supplementation ...
b-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
b-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. This is mainly achieved by its dual role as structural component of cadherin-based adherens junctions, and as a key nuclear effector of the Wnt pathway. For this dual role, different ...
Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
Apples are well known to have various benefits for the human body. Procyanidins are a class of
polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal
organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of ...
Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice
Abstract: Panax ginseng C. A. Meyer (ginseng) is an edible and medicinal Chinese herb, which
is often used in Asian countries for physical fitness. Ginseng is reported to have a wide range
of biological activity and pharmaceutical properties. There were more studies on ginsenosides
and polysaccharides, but fewer studies on ginseng oligop...
