Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer’s Disease: A Meta-Analysis of Case-Control Studies
Background: Many publications have investigated the association between metal ions
and the risk of Alzheimer’s disease (AD), but the results were ambiguous.
Aims: The objective of this study was to assess the association between the serum
levels of metals (copper/zinc/iron) and the risk of AD via meta-analysis of case-c...
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular ...
Zinc Signal in Brain Diseases
The divalent cation zinc is an integral requirement for optimal cellular processes, whereby it contributes to the function of over 300 enzymes, regulates intracellular signal transduction, and contributes to efficient synaptic transmission in the central nervous system. Given the critical role of zinc in a breadth of cellular processes, its cellular distribution and local tissue level concentrations remain tightly ...
Zinc and Oxidative Stress: Current Mechanisms
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules,
contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the ...
Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease
Background: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellular second
messenger that controls many processes associated with insulin signaling and other downstream pathways ...
Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. ...
Zinc Signals and Immunity
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency as well as zinc excess result in severe disturbances in immune cell numbers and activities, which can result in increased susceptibility to infections and development of especially inflammatory diseases. This review focuses on the role of zinc in regulating intracellular signaling pathways in innate as well as adaptive immune ...
Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized
Controlled Trial
Background: Data have shown that healthy children and adolescents have an inadequate intake of zinc, an essential nutrient for growth. It is unclear whether zinc supplementation can enhance bone health during this rapid period of growth
and development.
Objective: The primary aim of this study was to determine ...
