Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated
Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a
Native American Population
Background: Exposure to persistent organic pollutants (POPs) is known to increase risk of diabetes.
Objective: To determine which POPs are most associated with prevalence of diabetes in 601 Akwesasne Native Americans.
Methods: Multiple logistic regression ...
Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study
BACKGROUND: Some epidemiologic and laboratory studies suggest that insecticides are related to increased breast cancer risk, but the evidence is
inconsistent. Women engaged in agricultural work or who reside in agricultural areas may experience appreciable exposures to a wide range of
insecticides.
OBJECTIVE: We examined associations between ...
A Systems Biology Approach Reveals Converging Molecular Mechanisms
that Link Different POPs to Common Metabolic Diseases
A number of epidemiological studies have identified statistical associations between
persistent organic pollutants (POPs) and metabolic diseases, but testable hypotheses regarding underlying molecular mechanisms to explain these linkages have not been published.
Objectives: We assessed the underlying mechanisms of POPs ...
Synergistic Effects of Heavy Metals and Pesticides in Living Systems
There is a widespread repeated exposure of the population to the pesticides and
heavy metals of occupational and environmental origin. Such population is forced to
undergo continuous stress imposed by combined exposure of the heavy metals and
different classes of the pesticides used in agricultural as well as health practices. The
existing reports from several workers ...
Exposure to organophosphorus and organochlorine pesticides, perfluoroalkyl substances, and polychlorinated biphenyls in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC Study
Background: Studies report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Environmental chemicals may increase the risk of diabetes through impacts on glucose metabolism, mitocho...
Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats
Increasing evidence indicates that chlorpyrifos (CPF), an organophosphorus insecticide, is involved in metabolic disorders. We assess the hypothesis whether supplementation with prebiotics from gestation to adulthood, through a modulation of microbiota composition and fermentative activity, allevi...
Early-life chemical exposures and risk of metabolic syndrome
The global prevalence of obesity has been increasing at a staggering pace, with few
indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease ...
The Effect of Exposure to Persistent Organic Pollutants on Metabolic Health among KOREAN Children during a 1-Year Follow-Up
Previous evidence suggests the potential for adverse effects of persistent organic pollutants (POPs) on metabolic health even at low-dose exposure levels common among the general population, but there is less evidence of these associations among children. Therefore, as part of a prospective cohort study, 214 children ...
