Nutrição e Doença Celíaca – Artigo 13
Maternal and neonatal vitamin D status, genotype and childhood celiac disease
Background
Low concentration of 25-hydroxyvitamin D during pregnancy may be associated with offspring autoimmune disorders. Little is known about environmental triggers except gluten for celiac disease, a common immune-mediated disorder where seasonality of birth has been reported as a risk factor. We therefore aimed to test whether low maternal and neonatal 25- hydroxyvitamin D predicted higher risk of childhood celiac disease.
Methods and Findings
In this Norwegian nationwide pregnancy cohort (n = ...
Nutrição e Doença Celíaca – Artigo 12
Intestinal Microbiota and Probiotics in Celiac Disease
SUMMARY
Celiac disease (CD) is a common chronic autoimmune enteropathy caused by gluten intake. To date, the only therapy for CD is the complete exclusion of dietary sources of grains and any food containing gluten. It has been hypothesized that the intestinal microbiota is somehow involved in CD. For this reason, probiotics are appearing as an interesting adjuvant in the dietetic management of CD. This review aims to discuss the characteristics of the microbiota in CD subjects and the use of probiotics as a novel therapy for ...
Nutrição e Doença Celíaca – Artigo 11
Indications and Use of the Gluten Contamination Elimination Diet for Patients with Non-Responsive Celiac Disease
Abstract: For the majority of patients diagnosed with celiac disease, once a gluten-free diet is initiated, symptoms improve within weeks and may completely resolve in months. However, up to 30% of patients may show signs, symptoms or persistent small intestinal damage after one year on a gluten-free diet. These patients require evaluation for other common GI etiologies and assessment of their celiac disease status in order to make a diagnosis and suggest treatment. Here, ...
Nutrição e Doença Celíaca – Artigo 10
Effector and suppressor T cells in celiac disease
Abstract
Celiac disease (CD) is a T-cell mediated immune disease in which gliadin-derived peptides activate lamina propria effector CD4+ T cells. This activation leads to the release of cytokines, compatible with a Th1-like pattern, which play a crucial role in the pathogenesis of CD, controlling many aspects of the inflammatory immune response. Recent studies have shown that a novel subset of effector T cells, characterized by expression of high levels of IL-17A, termed Th17 cells, plays a pathogenic role in CD. While these ...
Nutrição e Doença Celíaca – Artigo 9
Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity
Abstract: Background: Intestinal exposure to gliadin leads to zonulin upregulation and consequent disassembly of intercellular tight junctions and increased intestinal permeability. We aimed to study response to gliadin exposure, in terms of barrier function and cytokine secretion, using intestinal biopsies obtained from four groups: celiac patients with active disease (ACD), celiac patients in remission (RCD), non-celiac patients with gluten sensit...
Nutrição e Doença Celíaca – Artigo 8
Dietary compliance in celiac disease
Abstract
Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small
intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results
and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in resolution of diarrhea, weight gain and normalization of nutrient malabsorption. In addition, histopathological
changes also normalize, but this histopathological response appears to be time-dependent, sex-dependent
and ...
Nutrição e Doença Celíaca – Artigo 7
Diet and Psoriasis: Part 2. Celiac Disease and Role of a Gluten-Free Diet
Abstract
Psoriasis patients have been shown to have a higher prevalence of other autoimmune diseases including celiac disease, a condition marked by sensitivity to dietary gluten. A number of studies suggest that psoriasis and celiac disease share common genetic and inflammatory pathways. Here we review the epidemiologic association between psoriasis and celiac disease and perform a metaanalysis to determine whether psoriasis patients more frequently harbor serologic markers of celiac disease. We also examine ...
Nutrição e Doença Celíaca – Artigo 6
Deficiencia de micronutrientes y enfermedad
celíaca en pediatría
RESUMEN
La enfermedad celíaca (EC) parece estar cambiando en su clínica, desde formas diarreicas con desnutrición hasta aquellas con clínica más silente y más tardía. La enteropatía de la EC ocurre con malabsorción de macro- y micronutrientes, que incluyen Fe, Zn, Cu, folato, Ca, vitaminas E, D, B12 y B6, con mecanismos de transporte
alterados. La anemia ferropriva se ha descrito en EC como única manifestación o como la manifestación extraintestinal más frecuente. La deficiencia de Zn es frecuente ...
