Nutrição e Envelhecimento – Artigo 15
Serum Tocopherol Levels and Vitamin E Intake are Associated with Lung Function in the Normative Aging Study
Abstract
Background and Aims—The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting. This study aimed to evaluate the effect of vitamin E intake and serum levels of tocopherol isoforms on lung function in a cross-sectional sample of 580 men from the Normative Aging Study, a longitudinal aging study.
Methods—Re...
Nutrição e Envelhecimento – Artigo 14
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
Abstract
All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model organisms ranging from yeast to non-human primates. In this review, we discuss ...
Nutrição e Envelhecimento – Artigo 13
Proteostasis, oxidative stress and aging
ABSTRACT
The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive
species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of
mammalian cells, systems are necessary which regulate and preserve a functional cellular protein pool, in a
process termed “proteostasis”. Not only the mammalian protein pool is subject of a constant turnover, ...
Nutrição e Envelhecimento – Artigo 12
Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease
ABSTRACT
A projected doubling in the global population of people aged $60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become at risk of “nutritio...
Nutrição e Envelhecimento – Artigo 11
Nutrition and other Lifestyle Influences on Arterial Aging
Abstract
As our world’s population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial function. Accumulating evidence demonstrates that diet and nutrition may favorably modulate these arterial ...
Nutrição e Envelhecimento – Artigo 10
Nutrition and lifestyle in healthy aging: the telomerase challenge
Abstract: Nutrition and lifestyle, known to modulate aging process and age‐related diseases, might also affect
telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation in stem cells and potentially in other cells by ...
Nutrição e Envelhecimento – Artigo 9
Nutrients, Microglia Aging, and Brain Aging
As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, ...
Nutrição e Envelhecimento – Artigo 8
MITOCHONDRIAL FUNCTION IN HYPOXIC ISCHEMIC INJURY AND INFLUENCE OF AGING
Abstract
Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment increases with age leading to dysregulation of molecular pathways linked to mitochondria. The perturbation of mitochondrial homeostasis and cellular energetics worsens outcome following hypoxicischemic insults in elderly individuals. In response to acute injury conditions, cellular machinery relies on rapid adaptations by ...
