Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review
In the present world scenario, obesity has almost attained the level of a pandemic and is progressing at a rapid rate. This disease is the mother of all other metabolic disorders, which apart from placing an added financial burden on the concerned patient also has a negative impact on his/her well-being and health in the society.
Among the various plausible factors for the ...
Dysbiotic drift and biopsychosocial medicine: how the microbiome links personal, public and planetary health
Abstract
The emerging concept of planetary health emphasizes that the health of human civilization is intricately connected to the health of natural systems within the Earth’s biosphere; here, we focus on the rapidly progressing microbiome science - the microbiota-mental health research in particular - as a way to illustrate the pathways by which exposure to biodiversity ...
Dysbiosis in Functional Bowel Disorders
Abstract
Functional bowel disorders (FBD) resemble a group of diseases of the gastrointestinal (GI) tract that are without a clear pathogenesis; the best known is probably the “irritable bowel syndrome” (IBS). Only recently we have been able to explore the role of the gut microbiota in FBD due to progress in microbiological analytic techniques. There are different ways to explore the role of the gut microbiota and its dysbiosis in FBD. ...
Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine
Chronic constipation is a prevalent functional gastrointestinal disorder accompanied with intestinal dysbiosis. However, causal relationship between dysbiosis and constipation remains poorly understood. Serotonin transporter (SERT) is a transmembrane transport protein which re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiolog...
Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells
Abstract
Vitamin D receptor (VDR) knockout (KO) mice had fewer Citrobacter rodentium in the feces than wild-type (WT) mice and the kinetics of clearance was faster in VDR KO than WT mice. VDR KO mice had more IL-22 producing innate lymphoid cells (ILC), and more anti-bacterial peptides than WT mice. The increased ILC in the VDR KO mice was a ...
Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases
Abstract: The human gut is heavily colonized by a community of microbiota, primarily bacteria, that exists in a symbiotic relationship with the host and plays a critical role in maintaining host homeostasis. The consumption of a high-fat (HF) diet has been shown to induce gut dysbiosis and reduce intestinal integrity. Recent studies have revealed that dysbiosis contributes to the progression of cardiovascular ...
Neurotoxicity from prenatal and postnatal exposure to methylmercury
Abstract
The extent to which postnatal methylmercury exposure contributes to neurobehavioral delays is
uncertain. Confounding may occur because the child's dietary exposure likely correlates with the
mother's. This conundrum was examined in the Faroese birth cohort 1 born in 1986–1987.
Exposure parameters included mercury concentrations in maternal hair at parturition, cord blood,
and child blood and hair at the ...
Mercury contamination in Southern New England coastal fisheries and dietary habits of recreational anglers and their families: Implications to human health and issuance of consumption advisories
Abstract
Total mercury (Hg) was measured in coastal fishes from Southern New England (RI, USA), and Hg exposure was estimated for anglers and family members that consumed these resources. Fish Hg was positively related to total length (n = 2028 across 7 fish species), and interspecies differences ...
