Colágeno e saúde – Artigo 13
Efficacy of Oral Collagen in Joint Pain - Osteoarthritis and Rheumatoid Arthritis
Abstract
Introduction: Joint pain is one of the most common types of chronic pain. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two leading causes of joint pain and there are currently no prophylactic or curative treatments available. Oral collagen has been implicated in providing a potential means to treat arthritis. This review article aims to identify, evaluate and summarize the results of ...
Colágeno e saúde – Artigo 12
The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials
Background Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a ...
Colágeno e saúde – Artigo 11
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study
Abstract
Background: Undenatured type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage. The purpose of this study was to evaluate the efficacy and tolerability of UC-II for knee osteoarthritis (OA) pain and associated symptoms compared to placebo and to glucosamine hydrochl...
Colágeno e saúde – Artigo 10
Effect of enzymatically cross-linked tilapia scale collagen for osteoblastic differentiation of human mesenchymal stem cells
Abstract
Type I collagen is an abundant component of bone tissue that has been used for bone tissue engineering using various cross-linking methods, including chemical agents, ultraviolet irradiation, and dehydrothermal treatment to enhance its physical properties. Collagens derived from mammalian animals are generally not used for implantable scaffolds owing to the ...
Colágeno e saúde – Artigo 9
Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology
ABSTRACT In this double-blind, placebo-controlled clinical study, we investigated the efficacy of specific bioactive
collagen peptides (BCP) on the cellulite treatment of normal and overweight women. In total, 105 women aged 24–50 years
with moderate cellulite were randomized to orally receive a daily dosage of 2.5 g BCP or a placebo over 6 months. The ...
Colágeno e saúde – Artigo 8
Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and antiinflammatory in murine posttraumatic osteoarthritis
Abstract
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease modifying therapies. Thus, strategies that offer chondroprotective or regenerative capability represent a critical unmet need. Recently, oral consumption of a hydrolyzed type 1 collagen (hCol1) preparation has been reported to reduce pain in human OA and support a ...
Colágeno e saúde – Artigo 7
Cyclic Mechanical Stretch Induced Smooth Muscle Cell Changes in Cerebral Aneurysm Progress by Reducing Collagen Type IV and Collagen Type VI Levels
Abstract
Background/Aims: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear. In this study, we examine protein changes in cerebral aneurysm and human brain vascular smooth muscle
cells after cyclic mechanical stretch. We further explore the relationship ...
Colágeno e saúde – Artigo 6
Collagen-derived peptides modulate CD4þ T-cell differentiation and suppress allergic responses in mice
Abstract
Introduction: Collagen peptides have been widely used as a food supplement. After ingestion of collagen peptides, oligopeptides containing hydroxyproline (Hyp), which are known to have some physiological activities, are detected in peripheral
blood. However, the effects of collagen-peptide administration on immune response are unclear. In the present study, we tested the effects ...
