Glutamine Supplementation in Cystic Fibrosis: A Randomized Placebo-Controlled Trial
Summary. Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.
M...
ORIGINAL RESEARCH ARTICLES
INTRODUCTION Despite the availability of consensus guidelines for the treatment of vitamin D deficiency,
prospective trials are lacking to examine alternative dosing strategies for adult patients with cystic fibrosis (CF) who do not meet therapeutic goals with standard regimens.
OBJECTIVES The primary objective of this study was to determine the efficacy of high-dose cholecalciferol
supplementation in increasing serum vitamin D (25-OHD) levels in adult patients ...
Vitamin E supplementation in people with cystic fibrosis (Review)
A B S T R A C T
Background
People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency, including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive diBiculties. Vitamin E supplementation is widely recommended for people with cystic fibrosis and aims to ameliorate this deficiency. This is an updated version of the review.
Ob...
Vitamin K supplementation for cystic fibrosis (Review)
A B S T R A C T
Background
Malabsorption and deficiency of fat-soluble vitamins K may occur in cystic fibrosis, a genetic disorder aIecting multiple organs. Vitamin K is known to play an important role in both blood coagulation and bone formation, hence the role of supplementation of vitamin K in this category needs to be reviewed. This is an updated version of the review.
Objectives
To assess the eIects of vitamin K supplementation ...
Vitamin A supplementation for cystic fibrosis (Review)
A B S T R A C T
Background
People with cystic fibrosis and pancreatic insuIiciency are at risk of fat soluble vitamin deficiency as these vitamins (A, D, E and K) are co-absorbed with fat. Thus, some cystic fibrosis centres routinely administer these vitamins as supplements but the centres vary in their approach of addressing the possible development of deficiencies in these vitamins. Vitamin A deficiency causes predominantly eye and ...
Antioxidant supplementation for lung disease in cystic fibrosis (Review)
A B S T R A C T
Background
Airway infection leads to progressive damage of the lungs in cystic fibrosis (CF) and oxidative stress has been implicated in the etiology. Supplementation of antioxidant micronutrients (vitamin E, vitamin C, beta-carotene and selenium) or N-acetylcysteine (NAC) as a source of glutathione, may therefore potentially help maintain an oxidant-antioxidant balance. Glutathione or NAC can also be ...
Omega-3 fatty acid supplementation for cystic fibrosis (Review)
A B S T R A C T
Background
Studies suggest that a diet rich in omega-3 essential fatty acids may have beneficial anti-inflammatory eGects for chronic conditions such as cystic fibrosis. This is an updated version of a previously published review.
Objectives
To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associ...
TERAPIA NUTRICIONAL NA FIBROSE CÍSTICA: REVISÃO INTEGRATIVA
RESUMO:
A Fibrose Cística (FC) é o distúrbio genético que afeta principalmente as populações caucasianas, sendo rara entre os asiáticos e negros. Os problemas nutricionais e consequências da fibrose cística são multifatoriais e relacionados com a progressão da doença. Tendo em vista tais pressupostos a terapia nutricional apresenta-se de grande relevância no tratamento e prevenção de complicações decorrentes da ...
