Diet Influences Expression of Autoimmune Associated Genes and Disease Severity By Epigenetic Mechanisms in a Transgenic Lupus Model
Abstract
Objective—Lupus flares when genetically predisposed people encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally silenced genes. DNA methylation depends on both dietary transmethylation micronutrients and Erk-regulated DNA ...
Diet, Microbiota and Autoimmune Diseases
Abstract
There is growing evidence that the commensal bacteria in the gastrointestinal tract (the gut microbiota) influence the development of autoimmunity in rodent models. Since humans have co-evolved with commensals for millennia, it is likely that people, who are genetically predisposed to autoimmunity, harbor gut microbial communities that similarly influence the onset and/or severity of disease. Beyond the current efforts to identify such ...
Relationship of ExcessWeight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients
Abstract: Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A cross-sectional study was conducted in 130 female ...
Short-Term Patient Centered Nutrition Counseling Impacts Weight and Nutrient Intake in Patients with Systemic Lupus Erythematosus
Abstract
Background—Patients with systemic lupus erythematosus (SLE) are at risk for cardiovascular disease (CVD) due to increased prevalence of risks factors.
Objective—To evaluate the effect of patient-centered nutrition counseling on changes in nutrient, anthropometric, and lipids in SLE patients enrolled in a CVD prevention counseling program (CVD ...
The Prognostic Nutritional Index and Nutritional Risk Index Are Associated with Disease Activity in
Patients with Systemic Lupus Erythematosus
Abstract: The prognostic nutritional index (PNI), controlling nutritional status (CONUT) score and nutritional risk index (NRI) have been described as useful screening tools for patient prognosis in several diseases. The aim of this study was to examine the relationship between PNI, CONUT and NRI with clinical disease activity and damage in 173 ...
Nutrient Intake and Diet Quality in Patients with Systemic Lupus Erythematosus on a Culturally
Sensitive Cholesterol Lowering Dietary Program
ABSTRACT. Objective. To evaluate the effect of a culturally sensitive cholesterol lowering dietary program on energy, protein, fiber, vitamin and mineral intake, diet quality, and hemoglobin levels in patients with systemic lupus erythematosus (SLE).
Methods. Seventeen patients with SLE were randomized to a Step II diet intervention group or a ...
Diet and Systemic Lupus Erythematosus: A 4 Year Prospective Study of Japanese Patients
ABSTRACT. Objective. To investigate the associations of dietary factors with the occurrences of active disease and
vascular damage in female patients with systemic lupus erythematosus (SLE).
Methods. Clinical and questionnaire data were collected from 279 female patients with SLE in a 1995 baseline survey. Dietary nutrients were estimated by a semiquantitative food frequency questionnaire and disease ...
