Nutrição e Saúde Mitocondrial – Artigo 20
Skeletal Muscle-Specific Overexpression of PGC-1α Induces Fiber-Type Conversion through Enhanced Mitochondrial Respiration and Fatty Acid Oxidation in Mice and Pigs
Abstract
Individual skeletal muscles in the animal body are heterogeneous, as each is comprised of different fiber types. Type I muscle fibers are rich with mitochondria, and have high oxidative metabolisms while type IIB fibers have few mitochondria and high glycolytic metabolic capacity. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), a transcriptional co-activator that regulates mitochon...
Nutrição e Saúde Mitocondrial – Artigo 19
Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing
Mitochondrial Function and Suppressing Autophagy
Sesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been shown to have potential anticancer activities. This study aims at characterizing the antitumor efficacy of sesamol and unveiling the importance of mitochondria in sesamol-induced effects using a human hepatocellular carcinoma cell line, HepG2 cells. Results of this study showed that sesamol treatment suppressed colony formation, elicited S phase arrest during cell cycle ...
Nutrição e Saúde Mitocondrial – Artigo 18
Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1α signaling pathway
Abstract: Quercetin, a dietary flavonoid used as a food supplement, has been found to have protective effect against mitochondria damage after traumatic brain injury (TBI) in mice. However, the mechanisms underlying these effects are still not well understood. The aim of the present study was to investigate the effect of quercetin on the potential mechanism mediating these effects in the weight-drop model of TBI in male mice that were treated with quercetin or vehicle via ...
Nutrição e Saúde Mitocondrial – Artigo 17
Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats
High blood pressure, or “hypertension,” is associated with high levels of oxidative stress in the
paraventricular nucleus of the hypothalamus. While pomegranate extract is a known antioxidant that is thought to have antihypertensive effects, the mechanism whereby pomegranate extract lowers blood pressure and the tissue that mediates its antihypertensive effects are currently unknown. We have ...
Nutrição e Saúde Mitocondrial – Artigo 16
Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC-1a pathway as a potential mechanism
Abstract
The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC-1a pathway in putative neuroprotection. Wild-type mice were randomly assigned to four groups: the sham group, the TBI
group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBIinduced neuronal ...
Nutrição e Saúde Mitocondrial – Artigo 15
Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation
Polyunsaturated fatty acids are important nutrients for human health, especially omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have been found to play positive roles in the prevention of various diseases. However, previous studies have reported that excessive omega-3 fatty acids supplement during pregnancy caused side effects such as slower neural transmission times and postnatal ...
Nutrição e Saúde Mitocondrial – Artigo 14
Medium Chain Triglycerides enhances exercise endurance through the increased
mitochondrial biogenesis and metabolism
Abstract
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver
disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic
syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature ...
Nutrição e Saúde Mitocondrial – Artigo 13
Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet
Abstract: The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been proposed
to elicit different or even opposite effects, depending on the prevalence of catabolic and anabolic
states. We tested the hypothesis that leucine supplementation may exert different effects at ...
