Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling
Systemic lupus erythematosus (SLE) patients have increased prevalence of metabolic syndrome but the underlying mechanisms are unknown. Toll-like receptor 7 (TLR7) that detects single stranded-RNA plays a key role in antimicrobial host defense and also contributes to the initiation and progression of SLE both in mice and humans. ...
The association between diet and glucocorticoid treatment in patients with SLE
ABSTRACT
Background: Some studies suggest that the risk for and severity of systemic lupus erythematosus (SLE) can be modified by certain nutrients. The aim of this study was to investigate the association between diet and glucocorticoid (GC) treatment, as a proxy for disease activity, in patients with SLE.
Methods: We included 111 patients with SLE from the SLE ...
Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation
Abstract
Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is ...
Diet Influences Expression of Autoimmune Associated Genes and Disease Severity By Epigenetic Mechanisms in a Transgenic Lupus Model
Abstract
Objective—Lupus flares when genetically predisposed people encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally silenced genes. DNA methylation depends on both dietary transmet...
Diet, Microbiota and Autoimmune Diseases
Abstract
There is growing evidence that the commensal bacteria in the gastrointestinal tract (the gut microbiota) influence the development of autoimmunity in rodent models. Since humans have co-evolved with commensals for millennia, it is likely that people, who are genetically predisposed to autoimmunity, harbor gut microbial communities that similarly influence the onset and/or severity of disease. ...
Relationship of ExcessWeight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients
Abstract: Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A ...
Short-Term Patient Centered Nutrition Counseling Impacts Weight and Nutrient Intake in Patients with Systemic Lupus Erythematosus
Abstract
Background—Patients with systemic lupus erythematosus (SLE) are at risk for cardiovascular disease (CVD) due to increased prevalence of risks factors.
Objective—To evaluate the effect of patient-centered nutrition counseling on changes in nutrient, anthropometric, and lipids in SLE patients enrolled ...
